In order to realize the automatization of two dimensional layout for different type and irregular parts, the new algorithm-heuristic two-step search method is put forward.

This paper overviews the achievements and develepment trends of binary decision diagrams(BDD) optimization, focusing on exact ordering algorithm and dynamic heuristic ordering algorithm, and some proposals are given to improve the BDD optimization algorithm: taking advantage of non-complete enumerating method and utilizing the strategy of stochastic process dynamic programming.

Study on goal ordering heuristic based on distance;

QSPR models for the prediction of association constants for the inclusion complexation ofα-cyclodextrins of benzene based on the heuristic method and support vector machine;

QSAR study of blood-brain barrier permeation using the heuristic method and support vector machine;

Fuzzy systems identification with data transformation and heuristic methods;

Based on the basic oxygen furnace, the second metallurgy and continuous casting technology, the paper establishes an order-oriented CC plan optimized mathematical model and gives a reasonable solution with the two-phase heuristic algorithm.

Based on extensive researches on various heuristic methods, an objective-based heuristic algorithm was developed to solve the 2D rectangle packing problem.