Synthesis and in vitro cytotoxicity of naphthalimide polyamine conjugates as antitumor agents

In order to search for antitumor drugs with high activity and low toxicity,five novel phthalimide polyamine conjugates were synthesized and their structures confirmed by 1H NMR,13C NMR,MS and elemental analysis.

Chemical structure and immunoactivity of the glycoconjugates and their glycan chains from the fruit of Lycium barbarum L.;

The recent synthesis progress of glycoconjugate is reviewed,including the various methods of the glycosidic bond formation by chemical synthesis and the synthesis strategies of novel complex glycoconjugates,such as glycopeptides,glycoproteins and glycolipids.

Three water soluble camptochecin glycoconjugates,β-acetylglucosamine,β-galactopyranoside and β-lactopyranoside,and one lipid soluble camptochecin glycoconjugate,peracetyl-β-galactopyranoside,were concisely synthesized by using glycine and hexanedioic acid as linker,respectively.

Structure Elucidation and Immunoactivity Studies of Glycan of Glycoconjugate LbGp4 Isolated from the Fruit of Lycium barbarum L.;

Effects of glycoconjugate and its glycan isolated from Lycium Barbarum L on macrophage function;

Four glycoconjugates ( D glucose, D galactose, D lactose and D glucuronic acid) of oleanolic acid were synthesized through a facile approach.