The aims of this study is to investigate the modulating effects of Chinese medicine herb Ginseng water-soluble extracts(GS) on human microglial functionns and to develop GMSE to become an uesful therapeutic medicine of central nerve system(CNS) neurodegenerative disease,injury and ischemia.

Thrombin-induced microglial activation contributes to the degeneration of nigral dopaminergic neurons in vivo;

Microwave irradiation induced microglia activated and JAKs phosphorylated in rat hippocampus;

Proteinum Nogo-66 on expression of retinal microglia OX40L;

Activation of microglial/macrophages in the optic nerve of the rat with chronic elevated intraocular pressure;

Establishment of three dimensional separation in microglial proteome;

Acute damage of nigrostriatal system in MPTP-treated senescence accelerated mouse and damage-related microglial activation

The effect of traumatic occlusion on microglias in rat parabrachial nuc1eus and locus coeruleus;

Response of the microglias in rat brains to restraint stress;

[Objective] To study whether and how microglias(BV2)affect the neurotrophic acitvity of marrow stromal cells(MSC)after being stimulated with injured PC12 media.

Effect of amyloid beta-peptide on activated microglial cell excreting nitric oxide;

Morphological changes mediated by P2X7 receptor and its expression in microglial cells;

The effect of microglial cell activation induced by optic nerve transection on functional integrity of blood-retinal barrier;

RESULTS:Microglia marked with green fluorescence was observed in ischemic penumbra,indicating that microglia can be transplanted across the blood-brain barrier.