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1)  Antisense oligodeoxynucleotide (ASODN)
反义寡苷酸
2)  antisense oligonucleotides
反义寡核苷酸
1.
Stduy on inhibition of proferation of lens epithelial cells by Ccnd1 antisense oligonucleotides liposomes in rats;
Ccnd1反义寡核苷酸脂质体抑制大鼠晶状体上皮细胞增殖的研究
2.
Inhibiting effect of Ccnd1 antisense oligonucleotides liposomes on proliferation of lens epithelial cells after extracapsular lens extraction in rats;
Ccnd1反义寡核苷酸脂质体对囊外摘出术后大鼠晶状体上皮细胞增殖的抑制作用
3.
Inhibitory effects of c-myc antisense oligonucleotides on the proliferation of MKN-45 cells;
c-myc反义寡核苷酸对胃癌MKN-45细胞株增殖的影响
3)  antisense oligodeoxynucleotides
反义寡核苷酸
1.
Effects of Tiam 1 antisense oligodeoxynucleotides transfection on the invasive and migratory potentials of gastric cancer cells in vitro and vivo;
Tiam 1反义寡核苷酸转染对胃癌细胞体内外侵袭转移能力的影响
2.
c-myc antisense oligodeoxynucleotides in reversion of cisplatin resistance in ovarian cancer cell line COC1/DDP;
c-myc反义寡核苷酸对卵巢癌细胞COC1/DDP顺铂耐药的逆转作用
3.
Effects of antisense oligodeoxynucleotides on Nogo-A mRNA expression in injured optic nerves;
反义寡核苷酸抑制大鼠损伤视神经Nogo-A mRNA的表达
4)  Antisense oligodeoxynucleotide
反义寡核苷酸
1.
Effect of antisense oligodeoxynucleotide(ASODN) of survivin gene on inducing apoptosis and chemotherapy sensitivity of Gastric cancer cell;
Survivin反义寡核苷酸诱导胃癌细胞凋亡及对化疗药物的增敏作用
2.
C-myc antisense oligodeoxynucleotide inhibits the growth and induces apoptosis of SW480 cell;
C-myc反义寡核苷酸对结肠癌细胞SW480增殖及凋亡的影响
3.
Inhibitory effect of survivin antisense oligodeoxynucleotides on HepG2 cells by using polyamidoamine dendrimer as gene delivery system;
树形分子递送survivin反义寡核苷酸对HepG2细胞的抑制效应
5)  antisense oligonucleotide
反义寡核苷酸
1.
Effect of STAT3 antisense oligonucleotide and radiotherapy on hep-2 cells cycle;
STAT3反义寡核苷酸联合放疗对喉癌Hep-2细胞周期的影响
2.
Expression of GATA-3 regulated by antisense oligonucleotide and inhaled corticosteroids in an asthma model in mice;
反义寡核苷酸和激素干预对哮喘小鼠GATA-3表达的影响
3.
CD44-specific antisense oligonucleotide on pro-liferation and apoptosis of human trabecular meshwork cells;
CD44反义寡核苷酸对人眼小梁细胞增生与凋亡的影响
6)  P65 antisense oligonucleotids
P65反义寡核苷酸
补充资料:多聚肌苷酸多聚胞苷酸
分子式:
CAS号:

性质:又称聚肌胞苷酸,多聚次黄嘌呤核苷酸:多聚胞嘧啶核苷酸。系高分子多聚核苷酸类(polynucleotides)物质之一,由多聚肌苷酸和多聚胞苷酸单链组成双股多核苷酸链,其中碱基比率:次黄嘌呤(Ⅰ):胞嘧啶(C)=1:1。产品有钾盐或钠盐分子量>33×106。它有特征性减色性和熔点,在-20℃稳定。不论是冻干粉还是溶液,在制品中常含有氯化钠,是为了保持溶液态时达到等渗。先采用生物技术分别合成多聚肌苷酸和多聚胞苷酸单链,再在一定条件下把两条链复合而成双股而成。是人工合成的干扰素诱导物。人工合成的聚肌胞苷酸有类似病毒进入动物后在繁殖过程中所复制产生的双链RNA(dsRNA)一样,能诱导宿主细胞生成干扰素。同时也是强有力的免疫刺激剂,能增强单核吞噬细胞系统的防御功能,且对癌细胞有毒性效应。临床上用肌内注射等试用于肿瘤、血液病、病毒性肝炎及痘类病毒性感染,对带状疱疹、单纯疱疹有较好的疗效;对病毒性肝炎、病毒性角膜炎和扁平苔藓有明显疗效。也用于肿瘤的辅助治疗。但有低热、头昏、胸闷等副作用,故目前逐渐转入直接使用干扰素。

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