1) methyl (pyro) pheophorbide-a
(焦)脱镁叶绿酸a甲酯
3) methyl(pyro)pheophorbide-a
(焦)脱镁叶绿酸-a甲酯
4) methyl pyropheophorbide a
焦脱镁叶绿酸a甲酯
1.
After protecting the exocyclic carbonyl group at the 9-position with ethylene glycol in the presence of trimethylsilychloride, the vinyl group of methyl pyropheophorbide a was converted into formyl and acetyl groups by the reaction of addition and oxidations of vinyl group at the 2-position.
以(焦)脱镁叶绿酸a甲酯为起始原料 ,利用其 2 位乙烯基的加成和氧化反应将乙烯基转化成羟烷基 。
5) methyl pyropheophorbide-a
焦脱镁叶绿酸-a甲酯
1.
From methyl pyropheophorbide-a (1), the aldehyde chlorin 2 was obtained by the protection of ring-E and oxidation of vinyl group at 3-position.
以焦脱镁叶绿酸-a甲酯(1)为起始原料,通过E环保护和3-位乙烯基的氧化反应得到卟吩醛2,与长链烷基溴化镁的Grignard反应将3-位甲酰基转化为1-羟长链烷基,选用TPAP和N-甲基吗啉N-氧化物混合氧化剂对卟吩仲醇3的羟基进行氧化,生成3-位烷酰基焦脱镁叶绿酸-a衍生物4,再与长链烷基溴化镁进行Grignard反应,得到亲核加成产物卟吩叔醇5和还原产物3;以对甲苯磺酸催化,卟吩醇3和5在干燥苯中回流脱水,分别给出反式结构的3-位长链烷基单或者双取代的焦脱镁叶绿酸-a甲酯衍生物6和7。
2.
By using the electrophilic reaction of methyl pyropheophorbide-a with various electrophilic re- agents, the new 20-meso-(nitro and halogen)-substituted pyropheophorbide derivatives were obtained, the structures of which were characterized by UV, IR, 1H NMR spectra and elemental analysis.
利用焦脱镁叶绿酸-a甲酯与亲电试剂发生的取代反应,在焦脱镁叶绿酸-a甲酯的20-meso-位上分别引进硝基和卤原子,得到了20-meso位取代的焦脱镁叶绿酸衍生物。
6) zinc methyl pyropheophorbide-a
焦脱镁叶绿酸-a甲酯锌
1.
The continuative reaction with zinc acetate generates zinc methyl pyropheophorbide-a.
从叶绿素-a开始,经过中心镁离子的剔除和17-位尾端酯基的酯交换得到脱镁叶绿酸-a甲酯,在醋酸中回流以脱去132-位甲氧甲酰基转化为焦脱镁叶绿酸-a甲酯,继续与醋酸锌相互作用则生成焦脱镁叶绿酸-a甲酯锌。
补充资料：上甲
1.阴历每月上旬之甲日。 2.科举时代殿试成绩最优的一等，也称一甲。
说明：补充资料仅用于学习参考，请勿用于其它任何用途。
参考词条