1) dihydropyridazinone compounds
二氢哒嗪酮类化合物
1.
In order to search for more potent and less toxic antithrombotic agents, eleven derivatives of 6-(4-substituted-phenyl)-4, 5-dihydro~3(2H)-pyridazinones were designedand according to mechanism of action and structure-activity relationship of dihydropyridazinone compounds.
为了寻找优良的血小板聚集抑制剂，本课题依据二氢哒嗪酮类化合物的作用机理和构效关系，在保留二氢哒嗪酮类化合物基本结构的基础上适当延长碳链，引入各种不同的侧链及杂环，共设计并合成了十一个二氢哒嗪酮类化合物，均为首次报道。
2.
In order to search for more potent and less toxic antithrombotic agents twenty-eight derivatives of 6-(4-substituted aminophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinones and 6-(4- substituted aminophenyl)-4,5-dihydro-3(2H)-pyridazinoneswere designed and synthesized according to mechanism of action and structure-activity relationship of dihydropyridazinone compounds.
二氢哒嗪酮类化合物具有良好的心血管药理作用如抗血小板凝集和强心等，有的已成为药物如匹莫苯（pimobendan），有的已结束Ⅲ期临床研究如MCI-154，有些正在进行临床前研究如SMⅡ_4、Y909、DMDP和CCI-17810等，这类化合物在心脑血管疾病的治疗方面具有广阔的应用前景。
2) Pyridazinone acids
哒嗪酮酸类化合物
3) 1,6-dihydro-6-pyridazinone
1,6-二氢-6-哒嗪酮
4) pyridazinones derivativesi
哒嗪酮类衍生物
5) pyridazinone
[,pirə'dæzə,nəun]
哒嗪酮类
1.
Analogues of 6 [4 substituted phenyl]pyridazinones have potent activity against platelet aggregation.
6 4 (取代苯基 )哒嗪酮类化合物具有较强的抑制血小板聚集作用 。
6) pyridazinones
哒嗪酮类
1.
Synthesis and antiplatelet aggregative activity of 6-[4-(substituted amino acetamido-phenyl)]-4,5-dihydro-3(2H)-pyridazinones;
6-[4-(取代胺基乙酰胺基苯基)]-4,5-二氢-3(2H)哒嗪酮类化合物的合成及其抗血小板聚集活性研究
2.
Aim To study the antiplatelet aggregative activity of 6-(4-substituted acetamido-phenyl)-4,5-dihydro-3(2H)-pyridazinones inletting different secondary amino groups.
目的研究引入仲胺类基团对6-(4-取代乙酰氨基苯基)-4,5-二氢-3(2H)-哒嗪酮类化合物抗血小板凝集活性的影响。
3.
Synthesis and the antiplatelet aggregative activity of 6-(4-substituted acetamidophenyl)-4,5-dihydro-3(2H)-pyridazinones;
目的:研究引入杂环类基团对6-(4-取代乙酰氨基苯基)-4,5-二氢-3(2H)哒嗪酮类化合物抗血小板凝集活性的影响。
补充资料：6,15-二氢二蒽并哒嗪-5,9,14,18-四酮
分子式：C28H14N2O4
分子量：442.43
CAS号：81-77-6
性质：熔点470-500°C。水溶性<0.1 g/100 mL at 21°C。
分子量：442.43
CAS号：81-77-6
性质：熔点470-500°C。水溶性<0.1 g/100 mL at 21°C。
说明：补充资料仅用于学习参考，请勿用于其它任何用途。
参考词条