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1)  dihydropyrido[2,3-d]pyrimidines
二氢吡啶并[2,3-d]嘧啶
2)  2-thioxo-2,3-Dihydropyrid-o[2,3-d]pyrimidin-4(1H)-one
2-硫代-2,3-二氢吡啶并[2,3-d]嘧啶-4(1H)-酮
3)  pyrido[2,3-d]pyrimidine
吡啶并[2,3-d]嘧啶
1.
A series of pyrido[2,3-d]pyrimidine derivatives were synthesized by the three component reac- tion of arylaldehyde, malononitrile and 4-amino-2,6-dihydroxylpyrimidine in ethyl alcohol at 80 ℃ cata- lyzed by KF-Al2O3.
以芳醛、丙二腈和2,6-二羟基-4-氨基嘧啶为原料,在KF/Al2O3催化下以乙醇为溶剂,在80℃三组分一步合成了一系列吡啶并[2,3-d]嘧啶衍生物,有趣的是在空气氧化作用下进一步发生了芳构化作用。
4)  pyrano[2,3-d]pyrimidine
吡喃并[2,3-d]嘧啶
1.
A series of pyrano[2,3-d]pyrimidine derivatives were synthesized from arylidene malononitrile and 1,3-dimethyl barbital at 100癈 catalyzed by triethylbenzylammonium chloride (TEBAC) in water.
以芳亚甲基丙二腈、1,3-二甲基巴比妥酸为原料,以水为溶剂,在100℃以三乙基苄基氯化铵(TEBAC)为催化剂合成了一系列的吡喃并[2,3-d]嘧啶衍生物,该方法具有反应条件温和,产率良好(78%～90%)和环境友好等优点。
2.
One-pot three component condensation reactions of aromatic aldehydes,malononitrile,and barbituric acid were described for the preparation of a series of pyrano[2,3-d]pyrimidine derivatives under ultrasonic irradiation in aqueous media without catalyst.
报道了在超声波辐射下,水相中无催化剂下通过芳香醛与丙二腈、巴比妥酸的一锅反应,合成了一系列吡喃并[2,3-d]嘧啶衍生物。
3.
A series of pyrano[2,3-d]pyrimidine derivatives were synthesized by the reaction of aromatic al-dehyde,malononitrile and 2-amino-4,6-dihydroxylpyrimidine in the presence of benzyltrimethyl ammonium bromide in water at 80 ℃.
以芳醛、丙二腈和2-氨基-4,6-二羟基嘧啶为原料,以水为溶剂,在80℃以苄基三甲基溴化铵为催化剂一步合成了一系列的吡喃并[2,3-d]嘧啶衍生物,产物的结构通过IR,1H NMR和元素分析表征。
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5)  pyrrolo[2,3-d]pyrimidine
吡咯并[2,3-d]嘧啶
1.
Antifolate alimta (1) derived from pyrrolo[2,3-d]pyrimidine is a multitargeted antitumor agent and a novel synthetic route to it was established.
吡咯并[2,3-d]嘧啶类叶酸拮抗剂Alimta(1)是一种多靶向的抗癌药物,本工作建立了新的方法全合成该药物。
2.
Antifolate Alimta derived from pyrrolo[2,3-d]pyrimidine is a multitargeted antitumor agent, it can inhibit at least five major folate-dependent enzymes: thymidylate synthase(TS), dihydrofolate reductase(DHFR), glycinamide ribonucleo -tide formyltransferase(GARFT), aminoimidazole ribonucleotide formyl transferase (AICARFT) and C-1 tetrahydrofolate synthetase(C1-S).
吡咯并[2,3-d]嘧啶类叶酸拮抗剂Alimta是一种多靶向的抗癌药物,它能抑制至少五种叶酸依赖性酶:胸苷合成酶(TS)、二氢叶酸还原酶(DHFR)、叶酰多聚谷氨酸合成酶(FPGS)、甘氨酰胺核糖核苷酸转甲酰酶(GARTF)及C1-四氢叶酸合成酶(C1-S)。
6)  Piperamic acid
8-乙基-5,8-二氢-5-氧-2-(1-哌嗪)-吡啶[2,3-d]并嘧啶-6-羧酸
补充资料：2,6-二甲基-1,4-二氢-3,5-吡啶二羧酸二乙酯
分子式：C13H19NO4
分子量：253.30
CAS号：1149-23-1

性质：熔点176-183°C。

说明：补充资料仅用于学习参考，请勿用于其它任何用途。
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