Prospects on the application of toxicogenomics in assessing the safety of chemical compounds;

This review presented several new tools used in the nonclinical studies of the safety e-valuation, including biomarkers, toxicogenomics, toxicoproteomics, metabonomies, and systems toxicology.

In this paper, the research progress on the toxicogenomics and its application in both improving environmental health and preventing environmently related disease were reviewed.

Progress in ecotoxicogenomics and ecotoxicoproteomics;

Antigenotoxic activity against 4-nitroquinoline-1-oxide (4-NQO)of Bfidobacterium and Lactobacillus isolated from faecal sample of elderly people was studied using the shortterm bacterial assay SOS-chromotest, with Escherichia coli PQ37(sfiA:: lacZ) as the tester organism.

Examination about genotoxicity of root canal sealer;

Objective The micronucleus test was applied to evaluate the genotoxicity of a new nanocomplex HA-PA66 root filling material in vitro.

Principles of assessment of genotoxicity and cytotoxicity were introduced.

Detection of virulence genes in 118 strains of China Listeria monocytogenes;

Genomic analysis of the virulence genes in Escherichia coli harboring high pathogenecity islands of Yersinia enterocolitica isolated from diarrhea patients;

Variance of antibiotic resistance and virulence gene of Vibrio cholerae O139 in Hangzhou city;