AIM To establish a simple and practical method for the estimation of the inter-patient variability of cytochrome P450(CYP3A)enzyme activity and to predict drug concentration and parmacokinetics of etoposide with the variability of CYP3A in chidren patients with leukemia.

Objective: To establish a HPLC method for the determination of the drug concentration in bile after the injection of lomefloxacine.

It was found that SM2 was absorbed quickly and distributed widely, the concentrations in the tissues of heart, liver, lung, kidney and small intestine were all higher,facially, the drug concentration in the tissue of small intestine was highest.

Association between valproic acid plasma concentration and CYP2C19 gene ploymorphism;

Objective To investigate whether the sort of drugs causing drug eruptions complicated with drug-induced liver dysfunction are the same as those causing drug eruptions.

The levels of liver microsomal protein,cytochrome P-450(Cyt P-450)and b 5(Cyt b 5 ),liver drug-metabolizing enzymes were determined,respect.

【Result】 Intraperitoneal injection of Streptococcus suis resulted in a time-dependent modulation of hepatic drug-metabolizing enzymes activities in mice.