The expression of μ-opioid receptor mRNA in the brain tissue of morphine withdrawal rats was examined by RT-PCR,and effects of EA at Zusanli(ST36) on the body weight and expression of μ-opioid receptor mRNA of morphine withdrawal rat were observed.

Effect of CCK receptor antagonists on CaMKⅡα mRNA and protein of neuron in hippocampus of morphine withdrawal rats;

Effect of melatonin on the blood follicle stimulating hormone, luteinizing hormone and testosterone of the morphine withdrawal mice.;

Effect of acupuncture on emotion and level of amino acids after morphine withdrawal;

The effects of central 5-HT_1,5-HT_2 receptors on morphine withdrawal syndromes in rates;

Effect of intracerebroventricular injection of glutamic acid/MK-801/ketamine on morphine withdrawal syndrome in rats

Objective: To study the therapeutic effects of isoptin on morphine withdrawal syndromes in infantile SD rats.

Methods:Models of morphine depen- dent rats were established by back hypodermic injection in back locus coeruleus, periaqueductal gray matter, substantia nigra, lenticula, corpus amygdaloideun and hippocampus of morphine dependent rats were observed under optical microscope, and the results were compared with those of control group.

Six cerebral regions locus coeruleus, periaqueductal gray,substantia nigra, lenticula, corpus amygdaloideun, hippocampus and frontalis cortex related to dependence were observed in morphine dependent rats by transmission electron microscope(.