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1)  Inhibitor of base excision repair
碱基切除修复抑制剂
2)  Base excision repair
碱基切除修复
1.
Expression of DNA polymerase β induced by all-trans retinoic acid and dimethyl sulfoxide and change of the base excision repair in human esophageal cancer cells;
诱导分化的人食管癌细胞DNA聚合酶β和碱基切除修复功能的改变
2.
BACKGROUND & OBJECTIVE: Base excision repair (BER) genes play important roles in maintaining genomic stability and their abnormal expression are associated with several cancers.
背景与目的:碱基切除修复基因对于维护基因组稳定性具有重要的作用,其表达异常与多种肿瘤相关。
3.
Most members of the XRCC genes family participated in several DNA repair pathways, including base excision repair, homologous recombination repair and non-homologous end joining.
目前已鉴定的这一基因家族的多数成员均参与几种重要的DNA修复途径,包括碱基切除修复、同源重组修复和非同源末端重接。
3)  base excision repair gene
碱基切除修复基因
4)  base excision repair gene XRCC1
碱基切除修复基因XRCC1
5)  Repair inhibitor
修复抑制剂
6)  excision repair cross complementation-1
切除修复基因
1.
But due to the development of resistance to DDP and it s noxious side-effect during treatment, the use of DDP is limited in clinic, the development of resistance is related tightly with the increasing level of excision repair cross complementation-1(ERCC-1) in tumor s cell, the key to treat tumor is how to decrease the leve.
但由于耐药的产生和自身的毒副作用,限制了顺铂的临床使用,耐药的产生与肿瘤细胞内切除修复基因(ERCC-1)的水平上升有密切相关,如何降低肿瘤细胞内ERCC-1的水平成了治疗肿瘤的一个关键。
补充资料:肉毒碱棕榈酰转移酶抑制剂
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性质:能够抑制肉毒碱棕榈酰转移酶活性的一类化合物。肉毒碱棕榈酰转移酶与乙酰辅酶A一起在线粒体膜内外起转运乙酰基作用,其抑制剂与先天性缺乏该酶一样,使人体骨骼肌无法利用长链脂肪酸,可能引起血液中脂肪累积和肌肉痉挛。

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