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1)  VPA
丙戊酸盐
1.
To investigate the expression of brain-derived neurotrophic factor(BDNF) in mice with Parkinson s disease(PD),and to study the neuroprotective effects of valproate(VPA),the PD model was established by administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP) to C57BL/6 mice.
为观察Parkinson病(PD)小鼠脑源性神经营养因子(BDNF)含量的变化及丙戊酸盐(valproate,VPA)对BDNF表达的影响,探讨VPA对PD病神经元的保护作用,本研究采用C57BL/6小鼠1-甲基-4-苯基-1,2,3,6-四氢吡啶(1-methy1-4-phenyl-1,2,3,6-tetrahydropyridine,MPTP)法建立PD模型。
2.
Objective To investigate expressions of glial cell line-derived neurotrophic factor(GDNF) in mice with Parkinson’s disease(PD),and to study the neuroprotective effects of valproate(VPA ).
目的观察帕金森病小鼠胶质细胞源性神经营养因子(GDNF)含量的变化及丙戊酸盐(valproate,VPA)对GDNF表达的影响。
2)  cypionate
环戊丙酸盐
3)  Valerates
戊酸盐类
4)  pivalate [pai'væleit]
新戊酸盐
5)  amyl propionate
丙酸戊酯
1.
The appropriate conditions for synthesizing amyl propionate were as follows: the molar ratio of amyl alcohol to propionic acid=1.
用β沸石作催化剂合成丙酸戊酯,考察催化剂制备方法和合成条件对催化性能的影响。
6)  valproic acid
丙戊酸
1.
Design,synthesis and antitumor activity of ATRA and butyric acid or valproic acid prodrugs;
全反式维甲酸-正丁酸(丙戊酸)前体药物的设计、合成及抗肿瘤活性研究
2.
Effects of valproic acid on proliferation in ovarian cancer cell line SKOV3 cells in vitro;
丙戊酸对体外培养上皮性卵巢癌细胞SKOV3细胞增殖的影响
3.
Effects of CYP2C19 gene polymorphism on plasma concentration of valproic acid in patients with epilepsy;
CYP2C19基因多态性对癫痫患者丙戊酸血药浓度的影响
补充资料:丙戊酸
分子式:C8H16O2
分子量:144.21
CAS号:99-66-1

性质:无色液体。沸点221℃,相对密度1.1(24.5/4℃),折光率1.4250,闪点111℃。难溶于水。

制备方法:由二丙基丙二酸经消除脱羧而得。将二丙基丙二酸投入反应锅,加热至180℃,反应物渐渐熔化,逸出大量二氧化碳气体。消除反应结束后,减压蒸馏,收集112-114℃(0.93-1.06kPa)馏分,即为2-丙基戊酸,收率86%。

用途:该品与氢氧化钠溶液成盐,得到广谱抗癫痫熔药物丙戊酸钠,又称抗癫灵。

说明:补充资料仅用于学习参考,请勿用于其它任何用途。
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