Effects of cornus officinals iridoid glycoside on cellular model of alzheimer disease induced by protein phosphatase inhibitor okadaic acid;

(Scrophulariaceae),one new iridoid glycoside,7-O-acetylgardoside methyl ester(2)was isolated,together with twelve known compounds,gardoside methyl ester(1),verbascoside(3),leucosceptoside A(4),jionoside D(5),martynoside(6),2″-O-acetylmartynoside(7),uridine(8),adenosine(9),benzyl alcohol-O-β-D-xylopyranosyl-(1→2)-β-D-glucopyranoside(10),2-phenylethyl O-β-D-xylopyranosyl-(1→2)-β-D-glu.

Objective: To observe the change of nitric oxide(NO)and expression of nuclear factor-kappa B(NF-κΒ) in the cortex of cerebral infarction rat induced by photochemical reaction,and study the effect of extract from Cornus officinalis(whose main ingredient is iridoid glycoside) in the course of disease.

Isolation and identification of iridoid glycosides from Ilex pubescens;

Enrichment of iridoid glycosides from the 80% EtOH extract of Gardenia jasminoides Ellis by macroporous resin was studied.

The iridoid glycosides in crude and processed extracts from cornus officinals have been analyzed by high performance liquid chromatography-electrospray ionization mass spectrometry.