1) β-amino ketone
β-氨基酮
1.
1,and at room temperature for 10 h with CH3CH2OH as a solvent,the yields of β-amino ketones was obtained with 75%-91%.
1,以乙醇为溶剂,室温条件下反应10h,生成相应的β-氨基酮,产率达75%～91%。
2.
To explore novel antidiabetic drugs with high efficacy and low toxicity, sixteen new β-amino ketones containing a sulfadiazine moiety have been synthesized through Mannich reaction of sulfadiazine with p-bromoacetophenone and some aromatic aldehydes in the yields of 10.
为了寻求新颖的抗糖尿病药物,我们将芳香醛、对溴苯乙酮和磺胺嘧啶通过一步反应直接合成了16个未见报道的含有磺胺嘧啶结构的β-氨基酮化合物,制备方法简便、反应条件温和,收率为10。
2) β-Arylaminoketone
β-芳氨基酮
3) β-Amiomethyl ketone
β-氨基甲基酮
4) α-amino-β-keto-esters
α-氨基-β-酮酸酯
1.
The syntheses of α-amino-β-keto-esters (β-oxo dipeptides) were studied.
对α-氨基-β-酮酸酯(β-含氧二肽)的合成进行了探讨。
5) β-amino ketone derivative
β-氨基酮衍生物
1.
The three component “one-pot” Mannich reaction of acetophenone with aromatic aldehydes and aromatic amines catalyzed by Yb(OTf)3 afforded the corresponding β-amino ketone derivatives in high yields under mild conditions.
报道了稀土化合物Yb(OTf)3催化的苯乙酮、芳香醛和芳香胺Mannich反应,三组分“一锅法”合成了一系列的β-氨基酮衍生物。
2.
Twenty-three β-amino ketone derivatives(four new compounds) were synthesized by three components one-pot Mannich reaction of acetophenone,aromatic aldehydes and aromatic amines using rare earth methylsulfonate as the catalyst at room temperature.
室温下,稀土甲基磺酸盐催化苯乙酮、芳香醛和芳香胺的Mannich反应,三组分"一锅法"合成了23种β-氨基酮衍生物(其中4种为新化合物),其结构经1H NMR,IR和元素分析确证。
3.
To explore novel peroxisome proliferator-activated receptor(PPAR) agonists with high efficacy and low toxicity, thirteen new β-amino ketone derivatives containing a sulfamethoxazole moiety were synthesized directly through Mannich reaction in the yields of 39.
为寻找新型高效低毒的过氧化物酶体增殖物激活受体(PPAR)激动剂,通过Mannich反应一步合成了13个含有磺胺甲噁唑结构单元的未见报道的β-氨基酮衍生物,收率为39。
6) β-acetamido ketones
β-乙酰氨基酮
1.
Synthesis of β-acetamido ketones;
β-乙酰氨基酮类化合物的合成
补充资料：[α-(乙酰氨基)-β-羟基乙基]对硝基苯基酮
分子式：C11H12N2O5
分子量：252.23
CAS号：3123-13-5
性质：暂无
制备方法：用对硝基苯乙酮以溴素溴化，生成对硝基-α-溴代苯乙酮，然后与六亚甲基四胺成盐得对硝基-α-溴代苯乙酮六亚甲基四胺盐。将后者以盐酸水解得对硝基-α-氨基苯乙酮盐酸盐，进而以乙酸酐酰化并与甲醛、甲醇加成（羟甲基化）制得该品。
用途：氯霉素中间体。
分子量：252.23
CAS号：3123-13-5
性质：暂无
制备方法：用对硝基苯乙酮以溴素溴化，生成对硝基-α-溴代苯乙酮，然后与六亚甲基四胺成盐得对硝基-α-溴代苯乙酮六亚甲基四胺盐。将后者以盐酸水解得对硝基-α-氨基苯乙酮盐酸盐，进而以乙酸酐酰化并与甲醛、甲醇加成（羟甲基化）制得该品。
用途：氯霉素中间体。
说明：补充资料仅用于学习参考，请勿用于其它任何用途。
参考词条