2R-hydroxy-3-phenylpropanoic acid benzyl ester as fragment one wassynthesized from D-Phe through diazotization hydrolysis and esterification by benzylalcohol in a yield of 56%;(tert-Butoxycarbonyl-methyl-amino)-acetic acid asfragment two was obtained in a yield of 83% from glycine through Bocamino-protection and N-methylation;2-tert-Butoxycarbonylamino-3-methyl-pentanoic acid as fragment three.

In addition, macropous crosslinked polyacrylamide resin was chemically modified by using the N-methylation of amide, and the mechanical strength, swelling properties in aqueous solution, and adsorpti.

On one hand, the experiments indicate that H3PW12O40/SiO2 showed the higher selectivity for N-methylation in the preparation of N, N-bimethyl aniline.