Four chiral azacrown ethers were synthesized from rosin: N-dehyroabietyl monoaza-12-crown-4,N-dehyroabietyl monoaza-15-crown-5,N-dehyroabietyl monoaza-18-crown-6 and N-degrading-dehyroabietyl monoaza-12-crown-4,which were employed as phase-transfer catalysts in asymmetric Michael addition of 2-nitropropane to chalcone,affording the corresponding Michael addition products up to 35% ee.

Study on azacrown ether grafted chitosan(Ⅲ)-synthesis of dihydroxy mesocyclic diamine crosslinked chitosan;

A series-linked tricycle azacrown ether ligand H 2L (H 2L=1,10-dioxo-4,7,13,16-tetraaza-4,7-ethylene-13,16-ethylene-6,15-dioxo-5,14-diacetic acid cyclooctadecane) is synthesized.

\; Eight new complexes were prepared by the reaction of trimethyl gallium with azacrown ethers which contain the phenoxyl group.

Bifanctional reagents in synthesis of aza-crown ethers;

Therefore, aza-crown ethers have received much attention as receptors.

This paper reviews recent progress in the investigation of artificial nuclease, including "bifunctional cooperative catalysis", "dinuclear synergistic catalysis", "metal-free catalysis", and especially, the studies of aza-crown ethers as artificial nucleases and their interaction with DNA.