OBJECTIVE:To establish a RP-HPLC method for determination of the content of stepholidine in tablets.

The results showed that l tetrahydropalmatine ( l THP)、 dl tetra hydropalmatine ( dl THP) and l stepholidine ( l SPD), at doses 15, 30, 60 mg·kg -1 respectively, were able to inhibit significantly mice incidence of jumping, frequency of jumping and body weight loss, respectively.

Effect of l-tetrahydropalmatine and l-stepholidine on the glial fibrillary acidic protein in the chronic morphine-treated cerebral focal regions of rats;

A double-blind comparison trial of l-stepholidine in the treatment of schizophrenia inpatients;

AIM: To investigate clinical effects of l stepholidine(SPD) with dual D 1 agonistic and D 2 antagonistic actions in the treatment of schizophrenia.

Object To study the effect of l stepholidine (l SPD) on β adrenoceptors Methods The affinity of l SPD to β adrenoceptors was investigated by radioligand binding assay by means of competitive [ 3H] labelled Dihydro Aprenolol ([ 3H] DHA) specific binding The antagonism of l SPD on β adrenoceptors was tested on pig coronary artery rings in vitro.