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1)  propeptide
前导肽
2)  Prolipase ['prəulipeis]
前导肽脂肪酶
3)  propeptide
前肽
1.
To understand the secretory expression of heterologous protein in Bacillus subtilis, especially of those from eucaryotes, also to reveal the role of propeptide, two recombinant plasmids containing TPO gene were cloned in Bacillus subtilis with or without propeptide, named Pro-TPO, SP-TPO respectively.
利用PCR方法扩增得到枯草杆菌本身的表达调控序列SP(含有信号肽)和Pro序列(包含信号肽和前肽)。
2.
Myostatin is synthesized as a precursor protein that undergoes proteolytic processing events in order to generate the N-terminal propeptide and C-terminal biologically active molecule consists of 110 amino acid residues.
MSTN前体经体内蛋白酶水解后,产生N端的前肽分子和C端包含110个氨基酸残基的活性分子。
4)  α factor secretion signal
α性成熟因子前导肽
5)  presequence
导肽
6)  prodynorphin
前强啡肽
1.
) application antisense oligodeoxynucleotide (AS-ODN) to induce prodynorphin (Pro-Dyn) mRNA and observed the degree of inflammatory edema after the formalin injection in rats to prove whether the quantity of dynorphin A in nerve centre could effect the degree of periphery inflammation.
目的:利用鞘内注射前强啡肽mRNA的反义寡聚核苷酸,观察由福尔马林引起的大鼠后脚炎性水肿程度的变化,来证明脊髓背角中强啡肽(dynorphin,Dyn)A的量可能影响外周炎症反应的大小。
2.
Total RNA in hippocampus was extracted and primers of enkaphalin or prodynorphin were respectively added for RT-PCR reaction.
方法:采用单纯束缚的方法建立慢性束缚性应激的大鼠模型,提取海马总RNA,采用RT-PCR反应扩增脑啡肽和前强啡肽基因,比较二者在海马中的表达情况。
3.
Aim: To investigate the changes of enkaphalin mRNA and prodynorphin mRNA gene expression in rat brain regions with chro-(nic) immobilization stress and the influence of Chinese herbs.
目的:研究慢性束缚应激时大鼠海马脑啡肽和前强啡肽mRNA基因表达的变化以及逍遥散、四君子汤、金匮肾气丸三种中药复方对其的影响。
补充资料:前导肽
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性质:又称前导肽。蛋白质分泌是生物界中极其普遍的现象。被分泌的蛋白质在分泌出膜外时其肽链的N端有一段肽结构。几乎所有的分泌的蛋白都含有信号序列。信号序列一般有20~40氨基酸长,在跨膜运输过程中,最终被信号肽酶除去。对原核生物中已知的信号肽分析,可发现有三个保守特点:(1)信号肽的N端有1~3个带正电荷的氨基酸残基;(2)N端的基本氨基酸后有一延伸的14~20个中性氨基酸部分,通常称作疏水中心(hydrophobic core);(3)信号肽切除部位附近的氨基酸有以下特点,可以表示为A-X-B。B紧接着切除位点(processing site)。可以是Ala,Gly或Set;A可以是上述氨基酸,也可以是Leu,Val或Ile。除上述三个基本特点外,许多信号肽的疏水中心区含有1或2个。螺旋不稳定的氨基酸残基如Pro或Gly。

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