Objective:To construct attenuated Salmonella delivering mouse hepatitis virus DNA vaccine and to study its immunogenicity.

Mouse Hepatitis virus(MHV) is a common coronavirus of laboratory mice.

Mouse Hepatitis Virus(MHV), a coronavirus of coronavirus genus, has a linear single-stranded RNA genome with positive polarity and causes a variety of diseases, such as enteritis, hepatitis and demyelinating encephalomyelitis in susceptible rodents depending on the virus strain, animal species and immune state of animals, etc.

Four different strains of mouse hepatitis virus (MHV), MHV 1, MHV 3, A 59 and JHM, were used to infect DBT cells.

Effect of antioxidase on testis cell apoptosis induced by nitrobenzene in mice;

Mutagenicity of nitrobenzene on bone marrow cells of mice;

The influence of subchronic samarium contamination on the reproductive ability of male mice, and grow of embryo and embryo rat;

Effect of Aroclor 1254 on early mouse embryo development in vitro;

Effects of low-frequency electromagnetic fieldon blood cells in mouse: An experimental study;

Developmental toxicity of lead acetate on mouse embryo in vivo;