Advance in SREBPs in Animal Lipid Metabolism;

The Study of the SREBPs;

Sterol regulatory element binding protein-1c and hepatic steatosis;

Objective:To evaluate the effect of Tiopronin on hepatic expression of sterol regulatory element binding protein-1c(SREBP-1c) in rats with alcoholic liver disease(ALD).

Objective To investigate the expression of sterol regulatory element binding proteins-1c(SREBP-1c)in the liver tissues during fatty diet-induced non-alcoholic steatohepatitis(NASH) in rats and to explore the relationship between the expression of SREBP-1c and nonalcoholic steatohepatitis.

Objective To explore the relationship between the 54G/C single nucleotide polymorphism of exon 18c of sterol regulatory element binding proteins-1c and type 2 diabetes mellitus in Chinese Han population from Hubei province.

Advanced Research of SREBP-1c Transcriptional Regulation in Fatty Liver Formation;

Objective:To study the effect of TNF-α(Tumor Necrosis Factor-α) on the expression of Sterol Regulatory Element Binding Protein(SREBP) Cleavage-Activating Protein (SCAP) and SREBP-1c in a model of hepatocyte steatosis,so as to explore the role and possible mechanism by which TNF-αacts on the SCAP-SREBP-1c pathway of lipid synthesis in nonalcoholic fatty liver disease(NAFLD).

OBJECTIVE To study the therapeutic effect of Jueming prescription(JMP)on nonalcoholic fatty liver disease in obese rat model,and investigate its influence on the expression of sterol regulatory element binding-protein 1c(SREBP-1c)in the liver.