\ Recent researches have shown that endophytic fungi of medicinal plants can produce a large number of novel active secondary metabolites, and have become an important resource for searching novel active natural products.

Coculture of actinomycetes with Bacillus subtilis and its effect on the bioactive secondary metabolites

Studies on teratogenic effects of the secondary metabolites of Rhizotonia leguminicola on neonatal mice;

Studies on the secondary metabolites of a marine fungus isolate 4454 in the South China Sea;

Identification of Bacillus sp. CPU5 and characteristics of its secondary metabolite;

The effects of secondary metabolites of Rhizoctonia Leguminicola on T lymphocytes proliferation of cancer rats;

Study on the secondary metabolites from mangrove endophytic fungus 2090# from the South China Sea;

Antitumor screening of deep ocean water and sediment derived fungi and primary investigation of their secondary metabolites;

Preliminary research of bioactive metabolite produced by marine actinomyces M326;

Using anti-Bacillus subtilis activity as index,the minimal inhibitory concentration(MIC) of metabolite is measured,the stability of bioactive metabolite treated with different temperatures and pH is observed,the bioactive ingredients are extracted and dissolved by organic solvent,and sorted by paper chromatography.

Methods:Using anti-Bacillus subtilis activity as the index,the minimal inhibitory concentration(MIC) of metabolite was measured,the stability of bioactive metabolite treated with different temperatures and pH was observed,the bioactive ingredients were extracted and dissolved by organic solvent,and sorted by paper chromatography.