Review the regulation of mRNA translation initiation by branched-chain amino acids and their signal transduction mechanisms within this regulation process,which include the initiation of translation,the regulation of mRNA translation initiation by BCAAs(branched-chain amino acids) and the signal transduction mechanisms within the regulation process.

The mutation of mRNA translation initiation region influences interferon gene translation;

To date,RNA viruses of IRES-dependent translation initiation are discovered in the mammals, invertebrates and plants.

If the fragment was inserted in forward direction,the plasmid B50il was obtained and computer analysis revealed that a hairpin formed ahead of the translation initiation region(TIR)but not affected the TIR.

Improved expression and catalytic efficiency of (R)-carbonyl reductase in Escherichia coli by secondary structure optimization of mRNA translation initiation region

To examine of the effects of mRNA secondary structures in the TIR(translation initiation region) on the translation efficiency of foreign genes in COS-7 cells,four consecutive identical codons(6×ATT,3×ATT,6×GCC and 3×GCC) were introduced into luciferase gene downstream AUG to produce four luciferase gene variants with different TIR secondary structures.

coli and the secondary structure of translation initiation region.

The secondary structure of the translation initiation region (TIR) is a determinant factor for translation initiation rate, meanwhile, codon preference plays an important role, too.

We established a simple mathematical model that the degree of polyamine stimulation of mRNA translation was dependent on the structure of the Shine-Dalgarno (SD) sequence in Escherichia coli.