1) correlativity of in vivo and in vitro XS release
体内外释药相关性
4) in vitro-in vivo correlation
体内外相关性
1.
Stability and in vitro-in vivo correlation of nimodipine soft gelatin capsules;
尼莫地平软胶囊的稳定性和体内外相关性研究
2.
The in vitro-in vivo correlation(IVIVC) model is often established for the oral solid extended release drug product development in order to predict accurately and precisely the expected bioavailability characteristics for the product from dissolution profile characteristics study.
药物的体内外相关性(IVIVC)研究常用于口服固体制剂的研发,建立相关性模型的目的是通过体外的释放度试验结果来预测药物在人体的吸收情况。
3.
OBJECTIVE To establish an in vitro-in vivo correlation(IVIVC) model using an artificial neural network (ANN) and pharma-cokinetic model for clozapine pH-independent sustained release tablets.
目的应用人工神经网络并结合药动学模型建立氯氮平缓释制剂体内外相关性评价模型,应用此模型设计氯氮平非pH依赖性缓释片的处方。
5) in vitro and in vivo correlation
体内外相关性
1.
Objective:To study the in vitro and in vivo correlation of self-designed oxybutynin osmotic pump tablet.
0 h在犬一侧后肢静脉取血1 ml分离血浆待测),用Wanger Nelson法计算体内吸收百分数,并与相应时间体外累积溶出度线性回归,进行体内外相关性考察。
2.
Objective:To determine the plasma levels of sodium valproate sustain-release tablets after oral administration and to evaluate in vitro and in vivo correlation by Wanger-Nelson method.
结论:丙戊酸钠缓释片体内外相关性显著,释放度测定方法可有效控制丙戊酸钠缓释片的内在质量和预测其生物利用度。
3.
Objective:To study the pharmacokinetics and relative bioavilability of pentoxifylline osmotic pump controlled release tablets in rabbits,and investigate its in vitro and in vivo correlation.
7)ng·h·mL-1;且体内外相关性较好。
6) in vivo-in vitro correlation
体内外相关性
1.
Advances in research on in vivo-in vitro correlation of sustained-release oral dosage forms in traditional Chinese medicine;
中药口服缓控释制剂体内外相关性研究进展
2.
The in vivo-in vitro correlation of test formulation was also investigated.
方法18名男性健康志愿者随机分成2组,先后单剂量、多剂量自身对照交叉口服受试制剂和参比制剂后采血,采用HPLC法测定血药浓度,计算药动学参数,并考察受试制剂的体内外相关性。
补充资料：麻醉性镇痛药拮抗药
麻醉性镇痛药拮抗药
narcotic antagonist
是一类对麻醉性镇痛药有专一性拮抗作用的药物，根据其药理特性分为激动-拮抗药和纯粹的拮抗药，前者如烯丙吗啡，目前临床使用较少；后者如纳洛酮。
说明：补充资料仅用于学习参考，请勿用于其它任何用途。
参考词条