It has shown that the genes are quite different in the two sides of replication origin,and the synonymous codon usage in the genes has their bias.

We have integrated synonymous codon usage information into the amino acid propensities for different protein secondary structural units, which are traditionally used in protein secondary structure prediction method.

Site discrepancy of synonymous codon usage in SARS coronavirus and other viruses in Coronaviridae;

Method for the design of mRNA detecting genechip based on codon usage bias;

A comparison of synonymous codon usage bias was made in twenty species from micro to higher plants and animals which involves six Dicotyledoneae,four Monocotyledones,seven multicellular animals,two unicellular eukaryotes and one prokaryote (Escherichia coli).

In the post-genome era, a lot of investigations indicate that codon usage bias is widespread in both eukaryotic and prokaryotic genomes, and the "selection-mutation-drift" theory has been put forward to explaining the evolutionary mechanism of the codon usage bias.

In this study, a comparative analysis of the codon usage bias was performed in Aeropyrum pernix K1 and two other phy- logenetically related Crenarchaeota microorganisms (i.