2) HMG-CoA reductase
HMG-CoA还原酶
1.
Increase of copy number of HMG-CoA reductase and FPP synthase genes improves the amorpha-4,11-diene production in engineered yeast;
HMG-CoA还原酶和FPP合酶基因拷贝数对紫穗槐-4,11-二烯酵母工程菌产量的影响
2.
Effect of atorvastatin on HMG-CoA reductase expression in spontaneously hypertensive rats;
阿托伐他汀对自发性高血压大鼠HMG-CoA还原酶表达的影响
3.
Objective To explore the effects of the one-week swimming with different loads on the gene expressions of HMG-CoA reductase,LDL-R,SR-BI and StAR in Leydig cells of rats with exercise-induced low serum testosterone.
方法:大鼠在经过5周间歇性负重游泳训练(TA组),造成运动性血睾酮降低的基础上,停训1周(TB组),继续训练1周:维持原负荷(负重5%体重,1组/日,TC组)、负荷量加倍(负重5%体重,2组/日,TD组)、负荷强度增加(负重6%体重,1组/日,TE组),检测大鼠Leydig细胞胆固醇代谢关键环节上的HMG-CoA还原酶、LDL-R、SR-BI及StAR mRNA表达。
5) HMG-CoA reductase inhibitor
HMG-CoA还原酶抑制剂
1.
Synthesis and biological evaluation of condensed pyrrole-based HMG-CoA reductase inhibitors;
吡咯类HMG-CoA还原酶抑制剂的合成及生物活性
2.
A three-dimensional pharmacophore model of 3-hydro-3-methyl glutaryl coenzyme A (HMG-CoA)reductase inhibitors (RI) was developed based on 21 HMG-CoA reductase inhibitors from a rat liver.
利用Catalyst计算HMG-CoA还原酶抑制剂最优药效团由一个氢键受体,一个氢键给体,一个疏水基团和一个芳香环特征组成。
3.
Pitavastatin is a novel,fully synthetic HMG-CoA reductase inhibitor,which can significantly reduce low-density lipoprotein cholesterol(LDL-C),triglycerides(TG),and also increase high-density lipoprotein cholesterol(HDL-C).
匹伐他汀(pitavastatin)是新一代HMG-CoA还原酶抑制剂,能显著降低低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)及升高高密度脂蛋白胆固醇(HDL-C),药动学性质优良,具有肝细胞选择性,且毒性低,安全性好,具有抗动脉粥样硬化、促血管生成和抗炎作用。
6) HMG-CoA reductase inhibitors
HMG-CoA还原酶抑制剂
1.
Aim To seek and design new kinds of HMG-CoA reductase inhibitors.
目的寻找和设计新的HMG-CoA还原酶抑制剂。
2.
By using TLC and UV-spectrum detection,HMG-CoA reductase inhibitors produced by a strain of Monacus sp were assayed,and the optimum fermentation conditions were studied as well.
采用薄层层析-紫外吸收光谱法对一株红曲霉产生的HMG-CoA还原酶抑制剂进行分析测定,并对其发酵条件进行研究。
3.
Author discussed the impacts of different reference structures on building a pharmacophore model of HMG-CoA reductase inhibitors using DIStance COmparison method (DISCO).
目的:考察不同模板分子对距离比较法(DIStance COmparison,DISCO)构建HMG-CoA还原酶抑制剂药效团模型的影响。
补充资料：HMG-CoA reductase inhibitors
分子式：
CAS号：
性质：抑制HMG-CoA还原酶（EC1.1.1.88）活性的物质，如康白丁、拉伐他丁等，抑制胆固醇生物合成的重要中间体—甲羟戊酸酯的生成反应。该反应是由乙酰辅酶A合成胆固醇的限速步骤。这类抑制剂在临床上可用作降血脂和降胆固醇药以及动脉粥样硬化病预防药。
CAS号：
性质：抑制HMG-CoA还原酶（EC1.1.1.88）活性的物质，如康白丁、拉伐他丁等，抑制胆固醇生物合成的重要中间体—甲羟戊酸酯的生成反应。该反应是由乙酰辅酶A合成胆固醇的限速步骤。这类抑制剂在临床上可用作降血脂和降胆固醇药以及动脉粥样硬化病预防药。
说明：补充资料仅用于学习参考，请勿用于其它任何用途。
参考词条