Establishment of transgenic mice for hepatitis B virus core gene expression;

Expression of Recombinant HBcAg in Baculovirus Expression Vector System;

Construction and in vitro expression of bicistronic DNA vaccines containing hepatitis B virus core antigen and Flt3 ligand genes;

Preparation and application of discoloration dilution detecting anti-HBc antibody;

2%) belonged to three typical HBV infected models:modelⅠwas HBsAg (+),HBeAg (+) and HBcAb (+);model Ⅱ was HBsAg (+),anti-HBe (+) and anti-HBc (+); model Ⅲ was HBsAg (+) and anti-HBc (+).