Influence of low-dose naloxone on the pain-killing effect of opium receptor agonist

Dependent potency of endomorphin-1 and its regulation of μ opioid receptor;

Objective:To investigate the effects of agmatine by activation I1 imidazoline receptor on DAMGO-induced down-regulation and internalization of μ opioid receptor(MOR).

Objective To investigate the synaptic connections between endomorphin-immunoreactive(ir) terminals and μ opioid receptor-ir neurons in the superficial layers(laminae Ⅰ and Ⅱ) of the rat spinal dorsal horn.

Synapses between ENK immunoreactive terminals and GABAergic neurons bearing μ opioid receptor in the rostral portion of nucleus tractus solitarious in rat;

To observe the connections between leucine enkephalin (L ENK) , β endorphin (β END) or dynorphin (Dyn) immunoreactive terminals and glutamate decarboxylase (GAD)/μ opioid receptor (MOR) co existed neurons within the midbrain central gray (CG) in the rat, immunofluorescence histochemical triple staining technique was used.

The ultrastructural localization of μ opioid receptor (MOR) in the superficial layers of the cat spinal cord was investigated by electron microscopy.

Effect of glucocorticoid on μ-opioid receptor in morphine dependent rats;

In the present study, the immunofluorescence and double- immunofluoresence histochemical techniques were usedto examine the distribution of μ-opioid receptor(MOR) and co-localization of MOR-like irnmunoreactivity (LI) with sub-stance P (SP)-, calcitonin gene-related peptide(CGRP)-, and somatostatin(SOM)- LI in the ganglion cells of the trigeminaland dorsal root ganglia in the rat.