Methods The iodine uptake and expression of hNIS(human sodium/iodide symporter) mRNA in MCF-7 cells cultures were determined both before and after the intervention of all-trans retinoic acid (ATRA) for various hours with iodine uptake assay and RT-PCR.

Preparation and characterization of type Ⅲ sodium-phosphate cotransporter siRNA-loaded chitosan nanoparticles;

Progress of application study on sodium/iodide symporter as a radionuclide imaging and therapeutic gene;

With the method of enzyme-linked immunosorbent assay(ELISA),the antibodies to human sodium iodide symporter(NIS-Ab) were measured in 241 patients with autoimmune thyroid diseases(ATD)(Graves disease(GD) untreated 83 cases,GD treated 58 cases,GD remission 66 cases,and Hashimoto s thyroiditis patients 34 cases).

Objective: To construct a recombinant adenovirus containing the human sodium iodide symporter (hNIS) under the control of the human telomerase reverse transcriptase (hTERT) core promoter to express specially on tumor cells, and to investigate the feasibility of radioiodine therapy mediated by hNIS gene controlled with hTERT promoter.

Sodium iodide symporter (NIS) mediates the accumulation of iodide in thyroid follicular cells,and becomes the molecular biology basis to diagnose and treat benign and malignant thyroid diseases.