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1)  Cyclic citrullinated peptide
环瓜氨酸肽
1.
Objective To establish Dot-immuno-bloting(DIB) technique for anti-Cyclic citrullinated peptide(anti-CCP) antibody,and study its value in diagnosing rheumatoid arthritis(RA).
目的建立检测抗环瓜氨酸肽(CCP)抗体的斑点免疫印迹试验,探讨其在类风湿关节炎(RA)疾病诊断中的价值。
2.
Objective:In order to study humoral immune reaction and cellular immune reaction of rheumatoid arthritis(RA) patients with cyclic citrullinated peptide(CCP).
目的:为了研究类风湿关节炎(RA)患者对环瓜氨酸肽(CCP)的体液免疫反应和细胞免疫反应,分别采用酶联免疫吸附试验(ELISA)检测患者血清中抗CCP抗体,采用酶联免疫斑点试验(ELIspot)与MHC肽四聚体(tetramer)流式细胞术检测患者外周血单个核细胞(PBMC)中对CCP抗原特异的自身反应T细胞(CCP-ART细胞),观察所测抗CCP抗体、CCP-ART细胞与RA患者临床症状及常用血清学指标的相关性,分析两者对RA的诊断与病情判断价值。
3.
Objective To develop a highly sensitive,specific and simple enzyme linked immunosorbent assay(ELISA)for determination of anti-cyclic citrullinated peptide(CCP)antibody.
目的用生物素-链霉亲合素放大ELISA系统建立一种敏感、特异、经济简便的抗环瓜氨酸肽(CCP)抗体的测定法。
2)  Citrullinated protein
瓜氨酸肽
3)  Anti-cyclic citrullinated peptide antibody
抗环瓜氨酸肽抗体
1.
Clinical study and detection of anti-cyclic citrullinated peptide antibody in Rheumatoid Arthritis;
环瓜氨酸肽抗体在类风湿性关节炎中的检测及临床研究
2.
Diagnostic significance of combined testing of anti-cyclic citrullinated peptide antibody and hidden rheumatoid factor immunoglobulin M in patients with juvenile rheumatoid arthritis;
环瓜氨酸肽抗体和隐匿性类风湿因子免疫球蛋白M型在诊断早期幼年类风湿关节炎中的意义
3.
Evaluation of anti-cyclic citrullinated peptide antibody and other correlated antibodies in diagnosing rheumatoid arthritis;
环瓜氨酸肽抗体及相关自身抗体在类风湿性关节炎诊断中的应用评价
4)  Anti-CCP antibody
抗环瓜氨酸肽抗体
1.
Objective Analyse the sensitivity and specific of Anti-CCP antibody and RF in patients with rheumatoid arthritis,to explore the value in diagnosting RA when the two antibody were used together.
目的同时检测抗环瓜氨酸肽抗体(Anti CCP抗体)和类风湿因子(RF)在类风湿关节炎(RA)中的敏感性及特异性,探讨两者联合检测在RA中的意义。
2.
Objective:Analyse the sensitivity and specific of Anti-CCP antibody,Anti-RA33 antibody and RF in patients with rheumatoid arthritis,to explore the value in diagnosting RA when the three antibodies were used together.
目的 :同时检测抗环瓜氨酸肽抗体 (Anti CCP抗体 )、抗RA3 3抗体和类风湿因子 (RF)在类风湿关节炎 (RA)中的敏感性及特异性 ,探讨三者联合检测在RA中的意义。
3.
Detection and significance of the anti-CCP antibody, anti-RA54, anti-Sa antibody and rheumatoid factor in patients with rheumatoid arthritis;
目的:探讨抗环瓜氨酸肽抗体、抗RA54抗体、抗Sa抗体和类风湿因子联合检测对早期类风湿性关节炎的 诊断意义。
5)  Anti-cyclic citrullinated peptide antibodies
抗环瓜氨酸肽抗体
1.
Diagnostic value of serum anti-cyclic citrullinated peptide antibodies in patients with rheumatoid arthritis;
对比检测血清中抗环瓜氨酸肽抗体水平对类风湿关节炎的诊断价值
2.
The study of Anti-cyclic citrullinated peptide antibodies and rheumatoid factors with the disease activity of rheumatoid arthritis;
环瓜氨酸肽抗体类风湿因子与类风湿关节炎活动度及骨侵蚀相关性的研究
6)  anti-cyclic citrullinated peptide
抗环瓜氨酸多肽抗体
1.
Influence of different samples on result determining anti-cyclic citrullinated peptide with ELISA method;
不同标本对ELISA法测定抗环瓜氨酸多肽抗体结果的影响
补充资料:亮氨酸氨肽酶
分子式:
CAS号:

性质:蛋白质水解酶中的氨肽酶类(aminopeptidases)之一。这类酶能从多肽链上游离的氨基末端(N端)由外向里逐个地把氨基酸切下,故又称肽链外切酶(exopeptidases)。亮氨酸氨肽酶不是因为只能水解以亮氨酸(Leu)为N末端残基的肽键,而是水解以亮氨酸为N末端的肽键速度为最快才有这一名称由来。实际上它同样可作用于N末端的其他氨基酸。对猪肾来源的LAP(分子量约255000)研究较多,但来自其他生物源的LAP也很多。分子量约30万,由数个亚基构成。Mg2+或Mn2+是该酶催化作用所必需的。早期它常用于对多肽的氨基酸序列测定。通常把在pH值8.5,25℃下,每分钟能水解1μmol L-亮氨酰胺(L-leucinamide)的酶量为一个酶活单位。

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