Methods: The target compound was obtained from L-tryptophan via 6-step reactions, including the Pictet-Spengler condensation, methylation, aromatization, hydrolyzation, coupling reaction and hydrolyzation.

A novel phosphodiesterase type-5 inhibitor, Tadalafil in a total yield of 64%, was synthesized from D-tryptophan by Pictet-Spengler condensation, N-acylation reaction and cyclization.

METHODS Using tryptophan or 5-hydroxyl tryptophan and 5-substituted indole as starting materials,via the modified Pictet-Spengler reaction,pityriacitrin and its derivatives were synthesized.

A series of chiral 1,3-disubstituted-1,2,3,4-tetrahydro-β-carbolines were synthesized by highly stereoselective Pictet-Spengler reaction of L-tryptophan methyl ester hydrobromide with aldehydes via a crystallization-induced asymmetric transformation process.

The Pictet-Spengler reaction of tryptamine hydrohalides with aldehydes was studied.

A monomer of polyimide 2,2′-bis[4-(3-aminophenoxy)phenyl]propane was prepared from m-dinitrobenzene and bisphenol A through condensation reaction and hydrazine hydrate reduction with an overall yield of 85.

This paper researched the condensation reaction of 2-metylbenzimidazole and 2-methylbenzothio-zole with aromatic aldehyde in acetic anhydride to form 2-(benzimidazol-2-yl)-1-aryl-ethylene derivatives or 2-(benzothiozol-2-yl)-1-aryl-ethylene derivatives.

The experiments show that the condensation reaction doesn't take place without ultrasonic irradiation, otherwise with ultrasonic irriation the reaction not phly occurs in ordinary condition but also good result was obtained.

The application of 1,3-dicyclohexylcarbodiimide(DCC) used as condensation agent in organic synthesis;

Condensation of Benzaldehyde and Methanol Catalyzed by Niobic Acid;

Effect of solvent on diazinon condensation;