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1)  catenin antibody
β-catenin抗体
1.
Preparation of the anti-β-catenin antibody and its application in the pathological examination of colon cancers;
β-catenin抗体制备及在结肠癌病理检测中的应用
2)  beta-catenin
β-catenin
1.
Expression of Beta-catenin,cyclinD1 and C-myc Genes in Hepatocellular Carcinoma;
β-Catenin,cyclinD1及c-myc在肝细胞癌中的表达
2.
The modulations of beta-catenin and caspase-3 levels were investigated in the KM mouse embryo following maternal treatme.
用 RT-PCR 及蛋白质印迹技术,探测了过量维甲酸对昆明小鼠胚胎神经管中维甲酸受体α/β及β-catenin 和 caspase-3 基因表达的调整。
3.
Objects: To investigate the interaction between HBX protein and beta-catenin, illuminate the molecular mechanism in HBV-associated hepatocellular carcinoma (HCC) carcinogenesis and the important role of wnt/β-catenin signaling pathway in the generation/differentiation of many tissues.
目的:利用HBX腺病毒质粒载体,转染人肝细胞株L02,观察HBX对?-catenin表达量及转录活性的影响,研究HBX与Wnt/β-catenin信号转导通路中主要信号分子的相互作用,确定HBX与β-catenin的内在联系,旨在探讨HBV相关性HCC的发生机制,阐明Wnt/β-catenin信号转导途径在胚胎发育和肿瘤发生过程中的重要作用。
3)  β-catenin protein
β-catenin蛋白
1.
expression and the clinical signincance of survivin protein and β-catenin protein in primary hepatocellular carcinoma (HCC);
Survivin蛋白及β-catenin蛋白在原发性肝癌组织中的表达及其临床意义
4)  β-catenin gene
β-catenin基因
1.
Abnormalities of APC gene/β-catenin gene in Wnt pathway in desmoid-type fibromatosis;
韧带样型纤维瘤病Wnt通路中APC/β-catenin基因异常
2.
Objective To explore the relationship of the expression of β-catenin gene with pathological type of craniopharyngiomas and prognosis of the patients with craniopharyngiomas.
目的探讨β-catenin基因和颅咽管瘤病理类型及预后的关系。
3.
PurposeTo analyze the clinicopathologic features of desmoid-type fibromatosis, and to detect trisomy 8 and mutations of the APC gene and β-catenin gene in this tumor with a purpose of exploring the mechanism of the tumorigenesis and progression of this disease.
运用免疫组织化学EnVision~+两步法检测69例存档石蜡包埋组织中β-catenin、cyclinD1、c-myc、Ki-67等蛋白的表达;用DNA末端转移酶介导的缺口标记法(Terminal Deoxynucleotidyl Transferase biotin-dUTP Nick End Labeling,TUNEL)检测病变中细胞凋亡;用聚合酶链反应(PCR)-变性液相高效质谱分析(Denaturing High Performance Liquid Chromatography,DHPLC)-直接测序的方法检测APC和β-catenin基因突变。
5)  Wnt/β-catenin pathway
Wnt/β-catenin通路
1.
[Objective]To investigate the expression of β-catenin and β-catenin/Tcf complex, two key members in the Wnt/β-catenin pathway, in different differentiated nasopharyngeal carcinoma (NPC ), and elucidate the role of Wnt/β-catenin pathway in neoplastic cells differentiation of NPC.
【目的】探讨Wnt/β-catenin通路的枢纽分子β-catenin和β-catenin/Tcf复合体在不同分化程度鼻咽癌中的表达,进而阐明Wnt/β-catenin通路对鼻咽癌分化的作用。
6)  β-catenin/TCF signaling
β-catenin/TCF信号
补充资料:β-catenin
分子式:
CAS号:

性质: 原癌基因编码的蛋白质,参与钙依黏附蛋白(cadehrin)胞内结构域介导的信号转导的重要分子。正常细胞内它的浓度较低。在由它介导信号转导的结果中都发现APC(adenomatous polyposis coli,是一种肿瘤抑制蛋白质),是一个β-连蛋白信号转导的负调节剂。显然β-连蛋白在恶性肿瘤病因研究领域中占有相当重要的地位。一旦APC或β连蛋白发生突变,即可发生信号转导减弱,细胞增殖加快与抑制细胞凋亡等作用,这是至今所了解的正常细胞发生恶变的β-连蛋白作用分子机制。

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