Autosomal dominant congenital nuclear cataract caused by a deletion mutation in the βA1-crystallin gene;

Objective To search parkin gene deletion mutations at exons 1 to 6 in Chinese patients with praecox Parkinson s disease (PPD) and analyze them together with the clinical features of PPD.

Objective To characterize the deletions of mitochondrial DNA (mtDNA) in Chinese patients with Kearns-Sayre syndrome (KSS) and chronic progressive external ophthalmolegia (CPEO) and identify deletion mutations of mtDNA be the etiology of these diseases.

Construction and characterization of EHEC O157∶H7 ler gene deletion mutant;

In order to determine the effect of stx gene of EHEC O157∶H7, stx deletion mutant was constructed.

To investigate whether the binding of Grp75 and p53 would influence the viability of cells, we constructed the eukaryotic expression vector of Grp75 deletion mutant.

Aim: To study the application of the mutation-sensitive molecular switch in the two deletion hotspots of EGFR gene associated with lung cancer.

Objectives: To study the association between the etiology and the deletive mutations of exons 1 to 7 on Parkin gene patients with praecox Parkinson s disease (PPD) in GuangXi and analyze the clinical features of PPD.