In this review, the current progress on identification of the new antibiotics through silent gene activation was elucidated and the successful development of two antibiotics, MM2002 (angucyclines) and notinorhodin using the silent gene activation technique, was discussed in detail.

Gene targeting in livestock fibroblasts has proven extremely difficult to achieve, particularly on silent gene locus.

Research and countermeasure against the plant transgene silence;

With the widely application of transgene technology in the fields of high level biologies, more and more attention was payed to gene silence.

RNA interference(RNAi) is a phenomenon of gene silence induced by double stranded.

dsRNA-triggered gene-silencing;

RNA interference(RNAi) was dsRNAs (double-stranded)-induced sequence-specific gene-silencing mechanism.

Biological effects of RelB gene silencing on the dendritic cells derived from bone marrow;

Inhibition effects of gene silencing of ornithine decarboxylase on cervical cancer cell growth;