Application of Dexmedetomidine for Sedation and Analgesia in Intensive Care Unit;

Dexmedetomidine-Induced ERK Phosphorylation in Brain Tissue by Transactivation of EGF Receptors;

Dexmedetomidine (DEX), the pharmacologically active dextroisomer of medetomidine, an efficient and highly selective alpha-2 adrenoceptor agonist, was recently introduced into clinical practice(clinical anesthesia and intensive care unit) for its sedative, analgesic, and sympatholytic properties, with few adverse effect.

Advance in search for clinical use of dexmedetomidine in anesthesiology;

Conclusion Dexmedetomidine infusion has a certain protective effect on renal function with increase of urine output and decrease of BUN and FENa+ in septic rats.

Dexmedetomidine in the General Anesthesia:A Meta-analysis of Randomized Controlled Trials;

Dexmedetomidine versus Midazolam in Anesthetic Preoperative Administration:A Meta-analysis

Study on Clinic Pharmacokinetics and Pharmacodynamics of Dexmedetomidine Hydrochloride in Chinese;

The hypotic and sedative dexmedetomidine is a novel strong potent and highly selectiveα_2- adrenergic receptor agonist,together with retaining the awakened power of patients under active sedation.

HPLC-MS/MS study of clinical pharmacokinetics of dexmedetomidine hydrochloride injection;