1) axonopathy
轴突病变
1.
Objective To explore the role of axonopathy in the neuropathological mechanism of Alzheimer s disease(AD).
目的探讨轴突病变在阿尔茨海默病(Alzheimer’s disease,AD)发病机制中的作用。
2) axonopathy
轴突病
3) axonal degeneration
轴突变性
1.
We learned some philosophic implications of axonal degeneration,such as its role in cell cycle regulation and apoptosis.
轴突变性是中枢神经系统疾病的基本病理过程,但是由于把其作为轴突失去胞体营养后的被动死亡,长期未受到重视。
2.
Classically, axonal degeneration has been regarded as a passive process which is mainly resulting from the lack of nutrition from the soma and a nonreversible primary lesion process which is no way to rescue.
既往认为,轴突变性是轴突损伤后缺乏来自胞体的营养物质而产生的被动死亡。
3.
Axonal degeneration is a common pathological change of neurogenical disease, which often occurs in diseases such as nerve injury,neurotoxic injury,neuro-degeneration and amyotrophic lateral sclerosis,e tal.
神经轴突变性(axonal degeneration)是神经源性疾病中常见的一种病理变化,常发生于神经损伤、神经中毒、神经退行性变及多发性硬化等多种疾病。
4) pathogenic mutation
致病突变
1.
AIM: To construct recombinant eukaryotic expression vectors pEGFP-C3-SNCA containing human wild-type(WT) and pathogenic mutations A30P,A53T α-synuclein(SNCA),and to obtain monoclonal PC12 cell lines overexpressing human wild-type and pathogenic mutations A30P,A53T α-synuclein by stable transfection.
目的:构建含人野生型及致病突变A30P、A53TSNCA基因的重组真核表达载体pEGFP-C3-SNCA,并通过稳定转染获得过表达人野生型及致病突变A30P、A53Tα-synu-clein(SNCA)的单克隆PC12细胞株。
2.
Aim : To clone human wild type SNCA gene and construct retroviral vector pEGZ/ MCS HA containing human wild type SNCA gene and its Ala30Pro,Ala53Thr pathogenic mutation.
目的:克隆人野生型SNCA基因,构建野生型SNCA基因及其致病突变Ala30Pro、Ala53Thr的逆转录病毒表达载体。
5) disease mutation
疾病突变
补充资料：神经元形态中枢神经系统内轴突髓鞘的形成示意图
李瑞端绘
[图]
说明：补充资料仅用于学习参考，请勿用于其它任何用途。
参考词条