Our previous studies showed that the vascular hyporeactivity is not only caused by the functional disorder of the K+ and Ca2+ cannels in vascular smooth muscle cell (VSMC), the hyperpolarization of VSMC membrane, but also by the calcium desensitization (the decrease of force/Ca2+ ratio) in VSMC.

Muscarinic receptor activities potentiated by desensitization of nicotinic receptors in rat superior cervical ganglia;

AMPA Receptor Desensitization and Fast Excitatory Synaptic Transmission;

Many factors which modulate the desensitization have been described,including composition of subunits,the affinity of ligand and receptor,phosphorylation,current potential of membrane,and so on.

Effects of renovascular hypertension on contractile/ diastolic function,calcium transient and calcium sensitivity in rat ventricular myocytes;

Relationship between calcium sensitivity regulation and vascular hyporeactivity following hemorrhagic shock;

Role of MLC_(20) phosphorylation in PKCα and PKCε regulating calcium sensitivity in cultured hypoxic VSMCs and in hemorrhagic shock rats;

Mechanisms of action of novel cardiotonic agents——calcium sensitizers;

Levosimendan is a new kind of calcium sensitizers with enhancing myocardial contractility and activating ATP-sensitive potassium channels,but without increasing intracellular calcium load;and thus providing anti-heart failure,anti-myocardial stunning,and decrease of peripheral vascular resistance,and together with relaxation of coronary artery and pulmonary vessels.

Now, there have been several classes of agents available for treatment of-congestive heart failure,such as endothelium receptor inhibitors,β-blockers,calcium sensitizers,diuretics,aldosterone receptor antagonists.

Expression of calcium sensing receptor during ischemia/reperfusion myocardial damage and relationship between CaSR and injury of myocardium;

Change of calcium sensing receptor expression and apoptotic pathways in myocardial infarction rat induced by isoprel