Relationship between JAK2 V617F point mutation and clinical characteristics of BCR-ABL negative myeloproliferative diseases patients;

Identification of disease-causing point mutations in DMD patients dystrophin gene without large deletions/duplications;

Study of mitochondrial DNA point mutations at positions 3243, 8993 in hereditary ataxia;

A research on the cusp catastrophe model of rockburst at the working surface of coal mining;

Application of cusp catastrophe model to the groundwater specific vulnerability assessment;

Study on ship rolling and capsizing based on the cusp catastrophe

Site-directed mutagenesis of functional gene fragment producing CTX-M-14-type extended-spectrum β-lactamase;

Study on site-directed mutagenesis and kinetics of trehalose synthase from Thermobifida fusca;

The Expression of hBmp-4 in the Pichia Pastoris and Its Site-Directed Mutagenesis;

Using recombinant glucagon expression system,the 21st aspartic acid was changed to be alanine by means of site directed mutagenesis.

Two p 16 mutants, P48L and D74N, were obtained by site directed mutagenesis using two step PCR method.

Human brain derived neurotrophic factor gene was used as template for oligonucleotide based site directed mutagenesis and PCR.