1) 5-HT1 receptor
5-HT1受体
1.
Methods: 5-HT1 receptors were originated from cerebral cortex, and 5-HT2 receptors from hippocampus of rats.
方法:5-HT1受体取材于大鼠大脑皮质,5-HT2受体取材于大鼠海马。
2) 5-HT_1 receptor subtype
5-HT1受体亚型
1.
To investigate the involvement of 5-HT_1 receptor subtypes in the transmission and modulation of the neuropathic pain, the expression of 5-HT_ 1A, 5-HT_ 1B, 5-HT_ 1D, 5-HT_ 1E and 5-HT_ 1F receptor subtype mRNAs in the spinal dorsal horn of the rat with spared nerve injury (SNI) was detected by reverse transcriptase-polymerase chain reaction (RT-PCR) technique.
为探讨脊髓内5-HT1受体亚型在神经病理性痛信息传递和调控中的作用,本研究利用反转录聚合酶链式反应(RT-PCR)技术观察了坐骨神经分支选择性损伤(SNI)模型大鼠脊髓背角内5-HT1A、5-HT1B、5-HT1D、5-HT1E和5-HT1F受体亚型mR-NAs表达变化。
3) 5-HT3 receptor
5-HT3受体
1.
Objective To study antiemetic mechanism and the clinical application of 5-HT3 receptor antagonists by researching the mechanisms of the chemotherapy-induced vomiting and the characteristics of the 5-HT3 receptors.
目的通过对5-HT3受体特点的研究和5-HT3受体参与的化疗致吐机制的剖析,阐明5-HT3受体拮抗剂对抗化疗致吐方面的作用机制和临床应用。
4) 5-HT4 receptor
5-HT4受体
1.
Objective To investigate the effect of 5-hydroxytryptamine(5-HT) and the plasticity of 5-HT3 and 5-HT4 receptors in the myenteric plexus on the pathogenesis of irritable bowel syndrome(IBS) subgroups.
目的探讨5羟色胺(5-HT)以及5-HT3、5-HT4受体可塑性在肠易激综合征(IBS)不同亚型发病中的作用。
2.
In addition,the stimulation of 5-HT4 receptors elicits gastrointestinal contractile activity and increases the rate of gastric emptying in humans and dogs.
而刺激5-HT4受体会引起人和犬的胃肠收缩动作并提高胃排空率。
3.
Aim To investigate the pharmacological effects of 5-HT4 receptor agonist SHR116958 on its prokinetic activity with in vivo and in vitro animal models.
目的通过3种小鼠整体和离体豚鼠回肠模型,研究新5-HT4受体激动剂SHR116958促进胃肠蠕动的作用。
5) 5-HT1A receptor
5-HT1A受体
1.
In the present study, extracellular recording was used to examine the neuronal activity of the basolateral nucleus (BL) of the amygdala and the effects of systemic administration of the selective 5-HT1A receptor antagonist WAY-100635 on the neuronal activity in the normal rats and rats with 6-hydroxydopamine (6-OHDA)-produced lesions in the substantia nigra pars compacta (SNc).
本文采用玻璃微电极细胞外记录法,观察正常大鼠和6-羟多巴胺(6-hydroxydopamine,6-OHDA)损毁黑质致密部大鼠杏仁基底外侧核(basolateral nucleus,BL)神经元电活动的变化,以及体循环给予选择性5-HT1A受体拮抗剂WAY-100635对神经元电活动的影响。
2.
The present study aimed to explore the effects of 5-HT1A receptors in the distal cerebral spinal fluid-contacting neurons (CSF-CNs) in rat brain parenchyma in neuropathic pain.
本文旨在探讨大鼠脑实质内远位触液神经元中5-HT1A受体的分布及其在神经病理性痛中的作用。
3.
Objective To explore the effects of citalopram on the expression of 5-HT1A receptor in the dentate gyrus in a rat model of post-stroke depression(PSD),and its pharmacological mechanisms in the treatment of PSD in rats.
day-1)干预4周,荧光实时定量PCR和Western印迹方法检测并比较CMS开始后第19、28天各组大鼠海马齿状回5-HT1A受体的基因(mRNA表达水平)和蛋白表达水平。
6) 5-HT2A receptor
5-HT2A受体
1.
To investigate the effects of nikethamide on the generation and modulation of rhythmic respiration of neonatal rats and the role of 5-HT2A receptor in this course, experiments were performed on the transverse medullary slices of neonatal rats (both sexes, 1- 3 d) in vitro.
本文旨在探讨中枢呼吸兴奋剂尼可刹米对新生大鼠基本节律性呼吸的产生和调节的影响及5-HT2A受体在其中的作用。
2.
Objective: To investigate the expression of nitric oxide synthase in the spinal cord following the blockade of 5-HT2A receptors of inflammatory tissues.
目的:研究阻断局部炎症组织中的5-HT2A受体后,脊髓背角一氧化氮合酶的变化,以了解外周5-HT2A受体在慢性炎症维持中的作用。
3.
Objective To investigate the changes of 5-HT2A receptor mRNA in rat vestibular nuclei during the adaptation of sea-sickness.
目的探讨晕船适应过程中大鼠脑干前庭核5-HT2A受体 mRNA的变化。
补充资料：N-受体
N-受体
存在于交感神经和副交感神经节、神经元的突触后膜和神经肌肉接头的终板膜上的受体。能与乙酰胆碱结合产生兴奋性突触后电位和终板电位，导致节后神经元和骨骼肌的兴奋。这类受体也能与烟碱相结合，产生相似的效应，故又称为"烟碱型受体"。据N型受体存在部位的不同，又分成两个亚型，存在于神经节神经元突触后膜上的受体为N2受体，存在于骨骼肌终板膜上的受体为Nl受体。
说明：补充资料仅用于学习参考，请勿用于其它任何用途。
参考词条