1)  LOH
LOH
1.
In order to detect the expression level and regulation mechanism of DNAJC10 gene in nasopharyngeal carcinoma(NPC),the expression state,methylation status,loss of heterozygosity(LOH) and mutation of DNAJC10 gene were examined by RT-PCR,MSPCR,LOH assay and sequencing respectively.
运用RT-PCR检测候选抑瘤基因DNAJC10在鼻咽癌组织中的表达,运用甲基化特异性PCR(MSPCR)技术、LOH和测序等技术分别检测DNAJC10基因在鼻咽癌组织中的甲基化状况、LOH和启动子突变情况。
2.
The aim of this study was to examine microsatellite instability (MSI) and loss of heterozygosity (LOH) of locus D17S396 on chromosome 17 and their influence on the expression of nm23H1 in the epithelial ovarian tumors, which may provide experimental basis for the mecha- nism of nm23H1 gene and tumor metastasis.
采用石蜡包埋组织抽提DNA,PCR-单链构象多态性(PCR-SSCP),常规银染、Envision免疫组织化学染色和Leica-Qwin计算机图像分析等方法,研究人类17号染色体D17S396位点微卫星不稳定(microsatellite instablility,MSI)和杂合性缺失(loss of heterozygosity,LOH),对卵巢上皮性肿瘤nm23H1蛋白表达的影响,阐明nm23H1基因遗传不稳定性与卵巢肿瘤进展的关系,为揭示nm23H1基因作用机制和肿瘤转移机制提供实验依据。
3.
To investigate microsatellite instability (MSI) and loss of heterozygosity (LOH) of locus D17S396, D17S579 and D17S855, and their effect on the expression of nm23H1 and BR- CA1 of gastric cancer, which would provide experimental basis for clinical treatment and prognosis analysis of gastric cancer.
结果发现,40例胃癌D17S396位点MSI、LOH检出率和nm23H_1蛋白阳性率分别为20。
2)  LOH
杂合性缺失
1.
Study on 10q23 LOH and Both Mutation and Expression of PTEN Gene of the Oesophageal Squamous Cell Carcinomas in Chinese Population;
中国人食管癌10q23杂合性缺失和PTEN基因突变及表达研究
2.
Methods PCR-denaturing polyacrylamide gel electrophoresis-silver staining method was used to detect LOH of three mic- rusatellite locus located in the WWOX gene site of 31 breast cancer tissues.
目的检测乳腺癌组织中WWOX基因的杂合性缺失(LOH)状况及WWOX蛋白的表达状况,并探讨其与乳腺癌临床病理参数之间的关系。
3.
Objective:To detect the loss of heterozygosity(LOH) of ING1 gene microsatellite and the expression of p33ING1b protein in lung carcinoma and to investigate their association with the carcinogenesis of lung cancer.
目的:检测肺癌中抑癌基因ING1微卫星杂合性缺失(LOH)及其主要蛋白产物p33ING1b的表达情况,以探讨ING1基因改变与肺癌发生发展的关系。
3)  LOH
杂合性丢失
1.
The Relationship of MSI and LOH to Cervical Carcinoma and its Clinically Biological Significance;
微卫星不稳定性和杂合性丢失与宫颈癌相关性的研究
2.
Objective:To investigate TK gene mutation frequency and loss of heterozygosity (LOH)induced by Microcystin-LR by using human lymphoblastoid cell line TK6.
结论:体外2 4h染毒TK6细胞MCLR可致突变并表现出断裂剂特性,诱发杂合性丢失而非点突变。
3.
Objective To investigate the loss of heterozygosity (LOH) and the expression of nm23-H1 gene in laryngeal carcinoma.
目的　探讨nm2 3 H1基因在喉鳞状细胞癌中杂合性丢失 (LOH)及表达情况。
4)  LOH
杂合缺失
1.
Detection of allele-specific chromosome 3p25 by PCR -LOH in 35 cases of esophageal carcinoma;
食管癌患者3p25等位基因杂合缺失的初步研究
2.
Methods: We performed restriction fragment length polymorphism (RFLP) analysis by using the polymerase chain reaction (PCR) and primer sets of two DNA markers to examine loss of heterozygosity (LOH) from 3p in glioma samples.
方法 :应用 PCR技术配合限制性片段长度多态性 (RFL P)分析 ,对胶质瘤 3号染色体短臂3p2 4两个 DNA标志不同位点的杂合缺失 (L OH)进行检测。
5)  LOH
等位基因位点杂合性缺失
1.
Objective The aim of this study was to investigate the relationship between loss of heterozygosity(LOH) of the allele genes on 3p and the diagnostic value of NSCLC.
目的探讨人3号染色体短臂(3p)等位基因位点杂合性缺失(LOH)多区域联合检测的意义。
6)  LOH
杂合丢失
1.
Objective To detect LOH of Fas gene (exon 8) in fibroblasts of tissues from skin lesions of 15 patients with keloids.
结果　所检测的 15个瘢痕疙瘩标本 10 0 %有Fas基因外显子 8的杂合丢失 ,基因测序发现 11个标本共 4个位点存在基因突变。
参考词条
补充资料：trans-lohexyl)amino) carbonyl)amino)sulfonyl)phenyl)ethyl)-2-oxo
CAS：93479-97-1
分子式：C24H34N4O5S
分子质量：490.62
中文名称：格列美脲

英文名称：1h-pyrrole-1-carboxamide, 2,5-dihydro-3-ethyl-4-methyl-n-(2-(4-(((((4-methylcyc； trans-lohexyl)amino) carbonyl)amino)sulfonyl)phenyl)ethyl)-2-oxo；glimepirid；glimepiride；hoe 490；Amaryl

用途：降血糖药。
说明：补充资料仅用于学习参考，请勿用于其它任何用途。