1) tyrosine kinase receptor
酪氨酸激酶受体
1.
With the aim to examine the distribution of high-affinity neurotrophin receptors (tyrosine kinase receptors, TrkA, TrkB and TrkC) in the rat Scapa’s ganglion (vestibular ganglion, VG), Avidin-Biotin-peroxidase Complex (ABC) method of immunohistochemistry with diaminobenzidine (DAB) as the chromogen to identify the immunoreactivities was employed in the present study.
采用免疫组织化学的卵白素-生物素-HRP复合物(ABC)法,以二氨基联苯胺(DAB)为呈色剂,观察高亲和性的神经营养物质受体(酪氨酸激酶受体),即TrkA, TrkB和TrkC在大鼠Scapa神经节(前庭神经节,VG)中的分布。
2.
The progresses on the study of neurotrophic factors such as neurotrophins and their functional receptors tyrosine kinase receptors (Trks TrkA, TrkB, TrkC) have been made rapidly.
近年来, 对神经营养因子(neurotrophicfactors) 尤其是神经营养素(neurotrophins, N Ts) 及其功能性受体———酪氨酸激酶受体 Trk A、 Trk B、 Trk C 的研究进展迅速。
2) Receptor tyrosine kinase
受体酪氨酸激酶
1.
Expression and its clinical significance of receptor tyrosine kinase EphB1 in gastric carcinoma
受体酪氨酸激酶EphB1在胃癌中的表达及其临床意义
2.
Mer is one member of Axl receptor tyrosine kinase family, and its ligand Gas6 can stimulate activity of Mer receptor tyrosine kinase after binding it, and then activate the downstream signal transduction pathway, Mer participates in cell inflammation, apoptosis, tumorigenesis, thrombosis and hemostasis.
Mer是Axl受体酪氨酸激酶家族中的一员,其受体Gas6和Mer结合后可以激活Mer的酪氨酸激酶活性,并激活下游信号传导途径,在细胞炎症、凋亡、血液肿瘤发生发展以及血栓于止血等方面发挥作用。
3.
FLT3,a member of receptor tyrosine kinase III family,is primarily expressed by hematopoietic cells and plays a significant role in hematopoiesis and leukemogenesis.
FMS-like Tyrosine Kinase 3(FLT3)是一种受体酪氨酸激酶,在造血干细胞、前体B细胞等的增殖、分化以及存活中具有重要作用。
3) receptor tyrosine kinases
受体酪氨酸激酶
1.
Modulation of potassium channels by receptor tyrosine kinases:recent progress;
受体酪氨酸激酶调节钾离子通道功能的研究进展
2.
The epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases have close connection with the initiation, progression and progn osis of various malignancies.
表皮生长因子受体 (EGFR)家族的受体酪氨酸激酶与多种恶性肿瘤的发生、发展及预后等密切相关。
4) RTK
受体酪氨酸激酶
1.
Receptor tyrosine kinase (RTK) inhibitors targeting VEGF receptor is one of the most promising agents.
血管内皮细胞生长因子 (VEGF)是体内活性最强、专属性最高的促血管生成因子 ,故成为寻找血管生成抑制剂的重要靶点 ,其中靶向 VEGF受体酪氨酸激酶的抑制剂令人最为关注。
2.
Our study is aimed to investigate whether EphA3,which is a member of RTK family,can play a role in PCa progression and whether it can promote the transition of PCa from androgen dependent stage to androgen independent stage as well as the mechanism of its function.
本课题旨在阐明受体酪氨酸激酶家族分子EphA3能否在前列腺癌进展中发挥作用,能否促进前列腺癌从雄激素依赖向雄激素非依赖的转变,并探索其发挥作用的分子机制,为发现新的前列腺癌相关信号转导途径,发现新的药物靶标和诊断治疗方法奠定基础。
5) tyrosine receptor kinase
酪氨酸受体激酶
6) tyrosine kinase receptor A(Trk A)
酪氨酸激酶受体A
1.
Objective To explore the effects of the neonatal handling and the enriched environment on nerve growth factor(NGF)and its tyrosine kinase receptor A(Trk A)in the forehead cortex and hippocampus of neonatal rats.
目的探讨早期触摸和环境刺激对新生鼠额皮质、海马神经生长因子(nerve growth factor,NGF)及酪氨酸激酶受体A(tyrosine kinase receptor A,Trk A)的影响。
补充资料:酪氨酸蛋白激酶抑制剂
分子式:
CAS号:
性质:一类能抑制蛋白质酪氨酸激酶活性的化合物。酪氨酸蛋白激酶能特异性地将磷酸根转移到蛋白质的酪氨酸残基上使其磷酸化,是许多配体活化的生长因子受体和一些癌基因产物,在肿瘤组织中含量高。酪氨酸蛋白激酶抑制剂可作为ATP与酪氨酸蛋白激酶结合的竞争性抑制剂,也可作为酪氨酸的类似物阻断表皮生长因子受体的肽位点和酪氨酸蛋白激酶的编码,抑制细胞增殖,可望开发为抗肿瘤药物,但对完整细胞没有表现出选择性。
CAS号:
性质:一类能抑制蛋白质酪氨酸激酶活性的化合物。酪氨酸蛋白激酶能特异性地将磷酸根转移到蛋白质的酪氨酸残基上使其磷酸化,是许多配体活化的生长因子受体和一些癌基因产物,在肿瘤组织中含量高。酪氨酸蛋白激酶抑制剂可作为ATP与酪氨酸蛋白激酶结合的竞争性抑制剂,也可作为酪氨酸的类似物阻断表皮生长因子受体的肽位点和酪氨酸蛋白激酶的编码,抑制细胞增殖,可望开发为抗肿瘤药物,但对完整细胞没有表现出选择性。
说明:补充资料仅用于学习参考,请勿用于其它任何用途。
参考词条