2) Mutant c-kit gene
突变C-kit基因
3) C-kit gene
c-kit基因
1.
Analysis of c-kit gene mutations in gastrointestinal stromal tumors;
胃肠道间质瘤c-kit基因突变的研究
2.
Methods:In 50 cases of GIST exon 9,11,13 of c-kit gene and exon 12,18 of PDGFRαgene were sequenced by PCR amplification to analyze the rule of gene mutation in GIST.
目的:研究分析胃肠道间质瘤(GIST)中c-kit基因及PDGFRα基因突变特点,探讨其与肿瘤原发部位、临床病理特点及预后的可能关系。
3.
Purpose To investigate the expression of c-kit in human osteosarcoma and their relationships with clinicopathological parameters and prognostic value and then to determine mutational status of exons 11 and 17 of c-kit gene which provide theoretical foundation for predicting prognosis and targeted therapy.
目的探讨骨肉瘤中c-kit的表达与肿瘤生物学行为及预后的关系,检测c-kit基因的突变状态,为临床判断预后及靶向治疗骨肉瘤提供依据。
5) c-kit
c-kit基因
1.
Most GISTs have oncogenic c-kit mutations that engender constitutive activation of this receptor tyrosine kinase, resulting in increased cell proliferation and survival, and such mutations appear to play a key role in the pathogenesis of the majority of GISTs.
大多数GISTs存在c-kit基因功能获得性突变，而c-kit基因突变在GIST发病过程中发挥关键的作用。
补充资料：操纵基因突变体
分子式：
CAS号：
性质：因操纵子的操纵基因突变而导致调节蛋白无法与之结合的细菌突变体。其特点是操纵子结构基因所编码的与代谢作用直接有关的酶为组成型表达。
CAS号：
性质：因操纵子的操纵基因突变而导致调节蛋白无法与之结合的细菌突变体。其特点是操纵子结构基因所编码的与代谢作用直接有关的酶为组成型表达。
说明：补充资料仅用于学习参考，请勿用于其它任何用途。
参考词条