Therapy with endogenous angiogenesis inhibitor is not clinically practical because of the high doses required and the difficulty in producing them in a fully functional state.

Based on its function of blocking the new blood vessel forming of tumor,and with its safety,the use foreground of angiogenesis inhibitors as an anti-tumor drug was broad.

Cloning of the gene coding for tumor angiogenesis inhibitor Arresten and its transference to Nicotiana tabacum;