Experimental studies on CD3-melanoma bispecific antibody enhancing the cytotoxicity of LAK cells;

Construction and functional identification of a novel trivalent anti-ErbB2/anti-CD16 bispecific antibody;

Immunofluorescence marking and biological activity detecting of bispecific antibodies against human bladder carcinoma;

Prediction of three dimensional structure of bispecific antibodies linked by flexible peptide

Recently, several approaches such as monoclonal an tibodies, bispecific antibodies, low molecular weight tyrosine kinase inhibitors and gene therapy targeting the EGFR family of receptors for anti-tumor therapy have been developed, some of which are currently undergoing clinical trials.

Detection of SARS virus antibody in sera of non-SARS persons in Dalian;

After having successfully constructed and expressed the gene of the anti-CD3/anti-CD20 bispecific single-chain antibody (bscCD3×CD20), here we analyzed its in vitro bioactivity of mediating the lysis of Ramous human B-lymphoma cells in the presence of T-enriched human peripheral blood lymphocytes (PBL).

The synthetic gene with 1640bp encoding for the anti-CD3 /anti-CD20 bispecific single-chain antibody was designed and obtained by SOE (sp licing by overlap extension) PCR.

Bispecific antibodies including bispecific shingle-chain antibody?leucine zipper dimerized bispecific ScFv antibody? bispecific single-chain antibody-toxin are very useful bilolgical products to be used in the clinical diagnosis and therapy developed in recent years, here we mainly elaborate the research progress of the gene construction?linker design?expression products and their bio-activity.