1) PML gene
PML基因
1.
Objective:To construct the recombinant adenovirus plasmid carring human PML gene for further study.
将质粒PSG-PML与含有5型腺病毒右臂的质粒pPE3共转染至293细胞,产生含PML基因的重组腺病毒(Ad-pml),并经PCR及DNA测序鉴定。
2) PML-RARα gene
PML-RARα基因
1.
Aim: To construct a eukaryotic coexpression plasmid containing PML-RARα gene and human GM-CSF(hGM-CSF) gene,which was expected to be used as a modified DNA vaccine for acute promyelocytic leukemia.
目的:构建急性早幼粒细胞白血病(APL)PML-RARα基因与人粒巨噬细胞集落刺激因子(hGM-CSF)基因真核双表达载体,为利用DNA疫苗治疗APL奠定基础。
2.
Objective To construct the PML-RARα gene recombinant plasmid, which is expected to be used as a modified DNA vaccine for acute promyelocytic leukemia.
目的构建PML-RARα基因重组表达质粒,为发展PML-RARα基因疫苗提供实验依据。
3) PML-RARa fusion gene
PML/RARa融合基因
4) PML/RARαfusion gene
PML/RARα融合基因
1.
Methods FISH was used to detect the AML1/ETO fusion gene and/or PML/RARαfusion gene in 10 AML-M_2 cases,19 AML-M_3 cases and 11 AML cases undetermined as AML-M_2 or AML-M_3 by routine morphology,cytochemical staining and immunophenotyping.
方法对初发的经骨髓常规形态学、细胞化学染色和免疫分型初步诊断的10例AML-M2、19例AML-M3,11例AML不能确定为M2或者M3的患者,进行FISH技术检测AML1/ETO和/或PML/RARα融合基因,进而协助诊断和指导治疗。
5) PML/RARα fusion gene
PML/RARα融合基因
1.
PML/RARα fusion gene was detected by using reverse-transcription polymerase chain reaction (RT-PCR) technique.
为了了解CD117/CD11b在急性早幼粒白血病细胞初诊及治疗后的表达变化,探讨其表达变化对APL诊断和预后的意义,采用CD45/SSC双参数散点图设门方法进行三色或四色流式细胞术细胞表面及浆内分化抗原分析,应用RT-PCR技术检测骨髓中PML/RARα融合基因的mRNA表达。
2.
Detection of the PML/RARα fusion gene by RT PCR in acute promyelocytic leukemia (APL) blasts is not only critical to commence promptly the specific therapy with all trans retinoic acid (ATRA) or arsenic trioxide (As 2O 3), but also essential for the definition of PML breakpoint type and subsequent monitoring of minimal residual disease (MRD).
在急性早幼粒细胞白血病 (APL)细胞中迅速、准确检出PML/RARα融合基因对于及时应用全反式维甲酸 (ATRA)或亚砷酸 (As2 O3 )提高诱导缓解率、减轻出血导致的早期死亡至关重要 ,但目前临床上采用的嵌套式RT PCR方法繁琐且费时 ,亟待改进以满足临床APL快速、准确诊断的需要。
3.
A new kind of sandwich-type DNA electrochemical biosensor is designed to detect PML/RARα fusion gene in acute promyelocytic leukemia.
基于急性早幼粒细胞白血病(APL)中PML/RARα融合基因的碱基序列,设计了新型的锁核酸(LNA)修饰寡核苷酸作为捕获探针和信号探针,研究出一种基于"三明治"传感模式的电化学生物传感器对PML/RARα融合相关基因进行检测。
6) PML/RARα gene rearrangement
PML/RARα基因重排
补充资料：J基因
分子式：
CAS号：
性质： 为免疫球蛋白V区与C区之间的连接区(J区)编码的基因。
CAS号：
性质： 为免疫球蛋白V区与C区之间的连接区(J区)编码的基因。
说明：补充资料仅用于学习参考，请勿用于其它任何用途。
参考词条