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1)  allogeneic hematopoietic stem cell transplantation
同种异基因造血干细胞移植
1.
This study was aimed to investigate the correlation between the serum levels of IL-18 and acute graft versus host disease(aGVHD)in patients received allogeneic hematopoietic stem cell transplantation(allo-HSCT),and to explore the role of serum IL-18 levels in the pathogenesis of aGVHD so as to provide a reliable and early indicator for the diagnosis of aGVHD.
本研究探讨同种异基因造血干细胞移植(allo-HSCT)受者血清白介素18(IL-18)与急性移植物抗宿主病(aGVHD)的关系,查明血清IL-18在aGVHD发病中的作用,为临床早期预测aGVHD提供可靠指标。
2)  nonmyeloablative allogeneic stem cell transplantati on
非清髓同种异基因造血干细胞移植
3)  allogeneic hematopoietic stem cell transplantation
异基因造血干细胞移植
1.
Effect of donor CD4~+CD25~+ regulatory T cells on hematopoietic and immune reconstitution,GVHD and disease-free survival after allogeneic hematopoietic stem cell transplantation;
供者调控T细胞对异基因造血干细胞移植后造血与免疫重建、移植物抗宿主病发生及生存的影响
2.
Study on pulmonary complications occurrence and risk factor after allogeneic hematopoietic stem cell transplantation;
异基因造血干细胞移植后肺部并发症的发生和危险因素分析
3.
A tracking detection on chimerism after allogeneic hematopoietic stem cell transplantation;
异基因造血干细胞移植后嵌合状态的追踪监测
4)  allo-HSCT
异基因造血干细胞移植
1.
To investigate the relationship between the plasma levels of chemokine CXCL9/Mig and acute graft- versus- host disease (aGVHD) after allogeneic hematopoietic stem cell transplantation(allo-HSCT).
研究血浆炎性趋化因子CXCL9/Mig在异基因造血干细胞移植(allo-HSCT)前后的水平变化,以探讨该因子在急性移植物抗宿主病(aGVHD)发病中的作用。
2.
This study was aimed to eveluate the role of CCR5 on donor cells in recipient models received intensive conditioning, so as provide the scientific evidence for clinical application of allo-HSCT.
本研究评价供者CCR5在经过强化预处理的骨髓移植动物模型受者体内的作用,为今后的异基因造血干细胞移植的临床应用提供科学依据。
3.
Objective To evaluate the role of gene CCR5 on donor cells in models where intensive preconditioning of the recipient occurs,thus provide the scientific evidence for clinical experience of allo-HSCT.
目的评价供者CCR5在经过强化预处理的骨髓移植动物模型受者体内的作用,为异基因造血干细胞移植的临床应用提供科学依据。
5)  allogeneic stem cell transplantation
异基因造血干细胞移植
1.
Objective To explore the condition of cytomegalovirus(CMV) infection and interstitial pneumonia(IP) after allogeneic stem cell transplantation,and the effect of their prevention and treatment.
目的探讨异基因造血干细胞移植中巨细胞病毒(CMV)感染和间质性肺炎(IP)的预防和治疗。
2.
To establish a method for quantitative assessment of mixed hematopoietic chimerism by competitive polymerase chain reaction after nonmyeloablative allogeneic stem cell transplantation(NAST) using highly polymorphic short tandem repeats (STRs).
利用STRs的高度多态性等特性 ,用竞争性聚合酶链反应 (PCR)结合聚丙烯凝胶电泳、染色和凝胶成像分析等技术 ,建立定量检测异基因造血干细胞移植后供受者嵌合体的方法 ,用无关个体的DNA混合实验进行可行性和准确性研究 ,并同时做染色体分带进行对照。
3.
The author briefs the main research progress and way of the new developed nonmyeloablative allogeneic stem cell transplantation(NAST).
简述了国内外刚刚开展的非清髓异基因造血干细胞移植 (NAST)的主要研究进展和研究方向。
6)  Syn-HSCT
同基因造血干细胞移植
补充资料:造血干细胞刺激因子


造血干细胞刺激因子
hemopoietic sti?mulating factor,CSF

诱导辅助细胞释放CSF,进而活化干细胞,可明显升高白细胞水平,用基因重组产生的CSF-1可活化巨噬细胞杀肿瘤活性,刺激单核细胞产生干扰素,肿瘤坏死因子可刺激造血细胞增生,促进细胞成熟和功能活化等,有临床应用价值。
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