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1)  EPI-PBCA-NP
表阿霉素α-聚氰基丙烯酸正丁酯纳米粒
1.
Biological security preliminary assessment of a new type anti-tumor composite EPI-PBCA-NP;
表阿霉素α-聚氰基丙烯酸正丁酯纳米粒生物安全性的初步评价
2.
Object: To study the tolerable dose and the maximal toxicity-free concentration range of EPI-PBCA-NP when repeated doses were given to normal rats for a long time period, and to observe the target organs of the toxic action, the reversibility of tissue morphology and functions after withdrawal of EPI-PBCA-NP, so as to provide a theoretical basis for its clinical application.
目的:研究表阿霉素α-聚氰基丙烯酸正丁酯纳米粒(EPIpolybutylcyanoacrylate nanoparticles EPI-PBCA-NP)在长期重复给药情况下健康大鼠的耐受剂量,探索最大无毒性反应的安全剂量范围,毒副反应的靶器官以及停药后组织形态和功能的可逆情况,为临床试验提供依据。
2)  Epirubicin Polybutylcyanoacrylate nanoparticles
表阿霉素聚氰基丙烯酸正丁酯纳米粒
1.
Objective To evaluate the therapeutic effects of Epirubicin Polybutylcyanoacrylate nanoparticles against transplanted malignant liver tumor in rats via vena caudalis.
目的观察表阿霉素和表阿霉素聚氰基丙烯酸正丁酯纳米粒对移植性肝癌的治疗效果。
3)  MMC-PBCA-NP
丝裂霉素-聚氰基丙烯酸正丁酯-纳米粒
4)  mitomycin C-polybutylcyanoacrylate nanoparticles
丝裂霉素C聚氰基丙烯酸正丁酯纳米粒
5)  mitomycin C-polybutylcyanoacrylate magnetic nanoparticles
丝裂霉素C-聚氰基丙烯酸正丁酯磁性纳米球
1.
Preparation and characteristic evaluation of mitomycin C-polybutylcyanoacrylate magnetic nanoparticles;
丝裂霉素C-聚氰基丙烯酸正丁酯磁性纳米球的制备方法及性质研究
6)  p53DNA-Doxorubicin-polybutylcyanoacrylate
p53DNA-阿霉素-聚氰基丙烯酸正丁酯
1.
Preparation and Drug Content Study of p53DNA-Doxorubicin-polybutylcyanoacrylate Nanoparticles;
通过改变体系的Zeta电位和加入离子对试剂,进一步提高纳米粒的DOX药物含量,同时采用二步法制备p53DNA-阿霉素-聚氰基丙烯酸正丁酯纳米粒。
补充资料:4′-表阿霉素
分子式:
CAS号:

性质:又名表阿霉素,4′-表阿霉素,表比星。为阿霉素的同分异构体。橘红色结晶性粉末。熔点185℃(分解)。旋光度[α]D+274°(c=0.01,甲醇)。溶于水,微溶于乙醇,不溶于氯仿、丙酮等。在日光、高温和高湿度下不稳定,碱性溶液中迅速分解。抗瘤谱、作用机理、体内过程均类似阿霉素。用于恶性淋巴瘤、乳腺癌、肺癌、前列腺癌等。

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