The expression of NR2B subunit of the NMDA receptor in the spinal cord of rats with neuropathic pain;

Methods:Western blot technique and RT-PCR technique were used to determine the expression of NR1,NR2A and NR2B subunit protein and mRNA expression in Pb exposure rats brain cortex of frontal lobe,neocerebellum,hippocampus and corpora.

Objective: To investigate the potential mechanisms and the analgesic effects of intrathecal administration of Ro 25-6981, a selective antagonist of the NR2B subunit of NMDA receptors (NR2B), on neuropathic pain in rats.

Construction of expression vectors for C-terminally deleted NR2B subunit mutants and their application in the study of assembling of NMDA receptors;

So it was supposed that NR2B subunit played an important role in experience-dependent developmental plasticity and changes in NR2B expression would affect developmental plasticity.

1.Differential Roles of NR2A and NR2B-Containing NMDA Receptors in Activity-Dependent BDNF Gene Regulation and Limbic 2.CDKL5/STK9 RNA Interference Blocks Neural Radial Migration;