1) maximum tolerable dose
最大耐受量
1.
Methods Twenty mice were used to study the acute toxic reaction with intragastric administration of Xinmaishu soup at the maximum tolerable dose(MTD),0.
结果小鼠按照最大耐受量即0。
2.
[Object] Studying acute toxicity and maximum tolerable dose of Astragalus composition F3 new preparation.
[目的]研究黄芪成分F3新制剂的急性毒性和最大耐受量。
2) Maximum tolerance dose
最大耐受量
1.
[Methods]①Singly-treated test:The oral exposure maximum tolerance dose was determined in mice according to the previous results of acute toxicity tests.
[方法]①单次给药实验 :在以往急性毒性实验的基础上 ,对昆明种小鼠口服一次给药 ,分别得到nano_Fe3O4、nano_Fe3O4_Glu的最大耐受量。
2.
The maximum tolerance dose in mice was determined intravenously, intraperitoneally and intragastrically respectively.
采用尾静脉注射、腹腔注射、灌胃给药法测定小鼠对鲤鱼精巢DNA的最大耐受量;采用全自动血细胞计数仪血象分析法检测鲤鱼精巢DNA的安全性;采用磷酸三钠法检测血浆中尿酸含量;采用小鼠睾丸重量法检测性激素样作用。
3) maximum tolerance
最大耐受量
1.
The mice maximum tolerance of anti-seasickness oral solution was 100 times higher than that of clinical dosage.
方法进行小鼠最大耐受量试验。
2.
Results:maximum tolerance has no effects on mouse and its various data.
结果:最大耐受量对小白鼠各项指标观察均无影响。
3.
The maximum tolerance dose test was carried out in rats,after administration of sodium rosiglitazong and rosiglitazone maleate for 6 days,their plasma biochemical index for hepatic function of survival rats were measured by method of kinetic,bromocresol green and biuret reaction.
大鼠灌胃给予罗格列酮钠、马来酸罗格列酮进行最大耐受量实验,存活动物在给药后d6,用Kinetic法、溴甲酚绿法和双缩脲法,日立7020型自动生化分析仪上测定肝功的血浆生化指标。
4) maximum-tolerated dose(MTD)
最大耐受剂量(MTD)
5) Maximum tolerated dose
最大耐受剂量
1.
Objective: To evaluate the safety and maximum tolerated dose of nolatrexed dihydrochloride in patients with malignant tumors.
最大耐受剂量(MTD)为920mg·m~(-2)·d~(-1)。
2.
A phase Ⅰ clinical trial is primarily concerned with assessing the drug s safety,and one of the main objectives is to estimate the maximum tolerated dose of the dose.
在研究了新药第Ⅰ阶段临床试验最大耐受剂量估计方法的基础上,给出了基于启动规则的逐步连续重新评估方法(CRM),并与传统的Up-and-Down方法进行了模拟比较,结果表明:逐步CRM方法减少了受试人数,降低了受试者中毒人数的百分比,从而提高了该方法的临床可接受性。
补充资料:最大耐受量
最大耐受量(mtd),又称最大耐受浓度:指药物在动物实验中不引起实验动物的最大剂量或浓度。
说明:补充资料仅用于学习参考,请勿用于其它任何用途。
参考词条