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1)  topoisomerase
拓扑异构酶
1.
Identification of common species of dermatophytes by PCR-RFLP techniques targeting topoisomerase II gene;
拓扑异构酶II基因区PCR-RFLP法鉴别常见皮肤癣菌
2.
Investigation on the Raw Materials Plants Resources of Topoisomerase Inhibitor in Kunyu Mountain
昆嵛山拓扑异构酶抑制剂原料植物资源调查
3.
Objective To study the roles of DNA topoisomerases(Topo) in ovarian cancer TPT-resistant cells.
目的探讨DNA拓扑异构酶(Topoisomerase,Topo)在卵巢癌拓扑替康(TPT)耐药细胞A2780/TPT中的作用。
2)  topoisomerase Ⅱ
拓扑异构酶
1.
Objective To detect the expression of p53、multidrug resistance gene1(mdr1) gene,glutathione S-transferase(GST-π),lung resistance protein(LRP),topoisomerase Ⅱ(Topo Ⅱ),and to evaluate their relationship with staging and classification of cancer,differentiation degree,lymphatic metastasis,and tumor invasion.
目的检测食管癌组织中P53、多药耐药基因(mu ltidrug resistance gene1,MDR1)及其编码产物P-糖蛋白(p-glycoprote in,P-gp)、肺耐药蛋白(lung resistance prote in,LRP)、谷胱甘肽S-转移酶(glutath ione S-transferase,GST-π)、拓扑异构酶(topoisom eraseⅡ,TopoⅡ)的表达水平,探讨其与临床分期、分化程度、淋巴结转移、肿瘤浸润深度及病理分型的关系。
3)  topoiso-merase I
拓扑异构化酶
4)  DNA topoisomerase
拓扑异构酶Ⅰ
1.
Camptothecin (CPT) compounds specifically acting on DNA topoisomerase Ⅰ (TopoI) are promising antitumor drugs, and have been widely used in the clinic.
喜树碱类抗肿瘤药物是DNA拓扑异构酶Ⅰ(1bpoisomerase I,TopoI)的特异性抑制剂,目前已广泛应用于临床。
2.
Camptothecin(CPT)compounds are specific inhibitors of DNA topoisomerase Ⅰ(TopoⅠ)which have been widely used in the clinic.
喜树碱类抗肿瘤药物是临床广泛使用的DNA拓扑异构酶Ⅰ (topoisomeraseⅠ ,TopoⅠ )的特异性抑制剂。
3.
Camptothecin(CPT)compounds are specific inhibitors o f DNA topoisomerase Ⅰ(TopoI)and have been widely used in the clinic.
喜树碱类抗肿瘤药物是临床广泛使用的经典的作用于DNA拓扑异构酶Ⅰ的特异性抑制剂。
5)  topoisomerase Ⅱ(TOPⅡ)
TOPⅡ(拓扑异构酶)
6)  DNA topoisomerases
DNA拓扑异构酶类
补充资料:DNA拓扑异构酶抑制剂
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性质:一类能够抑制DNA拓扑异构酶活性的化合物。DNA拓扑异构酶参与催化各种遗传过程中DNA链的断开和再连接。DNA拓扑异构酶抑制剂有助于研究异构酶的作用方式和功能,已发现许多这种抑制剂可作为抗肿瘤药,如鬼臼素(epipodophyllotoxins)等一些拓扑酶Ⅱ的特异性抑制剂。

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