Advance in search for clinical use of dexmedetomidine in anesthesiology;

Conclusion Dexmedetomidine infusion has a certain protective effect on renal function with increase of urine output and decrease of BUN and FENa+ in septic rats.

Application of Dexmedetomidine for Sedation and Analgesia in Intensive Care Unit;

Dexmedetomidine-Induced ERK Phosphorylation in Brain Tissue by Transactivation of EGF Receptors;

Dexmedetomidine (DEX), the pharmacologically active dextroisomer of medetomidine, an efficient and highly selective alpha-2 adrenoceptor agonist, was recently introduced into clinical practice(clinical anesthesia and intensive care unit) for its sedative, analgesic, and sympatholytic properties, with few adverse effect.

Dexmedetomidine in the General Anesthesia:A Meta-analysis of Randomized Controlled Trials;

Dexmedetomidine versus Midazolam in Anesthetic Preoperative Administration:A Meta-analysis

Study on Clinic Pharmacokinetics and Pharmacodynamics of Dexmedetomidine Hydrochloride in Chinese;

The hypotic and sedative dexmedetomidine is a novel strong potent and highly selectiveα_2- adrenergic receptor agonist,together with retaining the awakened power of patients under active sedation.

HPLC-MS/MS study of clinical pharmacokinetics of dexmedetomidine hydrochloride injection;